Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.

Bibliographic Details
Main Authors:	Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21614-5

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spelling	doaj-254e1803533c4a90b127c4e96c993a342021-03-11T11:31:30ZengNature Publishing GroupNature Communications2041-17232021-03-0112111510.1038/s41467-021-21614-5Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)Kengo Watanabe0Kazuhiro Morishita1Xiangyu Zhou2Shigeru Shiizaki3Yasuo Uchiyama4Masato Koike5Isao Naguro6Hidenori Ichijo7Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoDepartment of Cellular and Molecular Neuropathology, Juntendo University Graduate School of MedicineDepartment of Cell Biology and Neuroscience, Juntendo University Graduate School of MedicineLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoCells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.https://doi.org/10.1038/s41467-021-21614-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo
spellingShingle	Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) Nature Communications
author_facet	Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo
author_sort	Kengo Watanabe
title	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_short	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_full	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_fullStr	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_full_unstemmed	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_sort	cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(adp-ribose)
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-03-01
description	Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.
url	https://doi.org/10.1038/s41467-021-21614-5
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Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

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