Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.
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Nature Publishing Group
2021-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-21614-5 |
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doaj-254e1803533c4a90b127c4e96c993a342021-03-11T11:31:30ZengNature Publishing GroupNature Communications2041-17232021-03-0112111510.1038/s41467-021-21614-5Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)Kengo Watanabe0Kazuhiro Morishita1Xiangyu Zhou2Shigeru Shiizaki3Yasuo Uchiyama4Masato Koike5Isao Naguro6Hidenori Ichijo7Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoDepartment of Cellular and Molecular Neuropathology, Juntendo University Graduate School of MedicineDepartment of Cell Biology and Neuroscience, Juntendo University Graduate School of MedicineLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of TokyoCells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.https://doi.org/10.1038/s41467-021-21614-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo |
spellingShingle |
Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) Nature Communications |
author_facet |
Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo |
author_sort |
Kengo Watanabe |
title |
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) |
title_short |
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) |
title_full |
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) |
title_fullStr |
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) |
title_full_unstemmed |
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose) |
title_sort |
cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(adp-ribose) |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-03-01 |
description |
Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation. |
url |
https://doi.org/10.1038/s41467-021-21614-5 |
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