NONMEM Tutorial Part II: Estimation Methods and Advanced Examples

NONMEM Tutorial Part II: Estimation Methods and Advanced Examples

In this second tutorial on NONMEM, the examples of typical pharmacokinetic/pharmacodynamic modeling problems that occur in the pharmaceutical field will be presented, which the reader can use as a template for his or her own modeling endeavors. Each of the problems presented is challenging in some w...

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Main Author: Robert J. Bauer
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12422
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spelling doaj-254f76bae2974fe499487a8c3a3c3e182020-11-25T03:14:51ZengWileyCPT: Pharmacometrics & Systems Pharmacology2163-83062019-08-018853855610.1002/psp4.12422NONMEM Tutorial Part II: Estimation Methods and Advanced ExamplesRobert J. Bauer0Pharmacometrics R&D ICON Clinical Research LLC GaithersburgMarylandUSAIn this second tutorial on NONMEM, the examples of typical pharmacokinetic/pharmacodynamic modeling problems that occur in the pharmaceutical field will be presented, which the reader can use as a template for his or her own modeling endeavors. Each of the problems presented is challenging in some way, and the logic behind setting up each problem is discussed. Logical concepts of the problem itself as well as the technical aspect of how to set it up in NONMEM are described and demonstrated. The concepts behind the various estimation algorithms will first be described to allow the user a better understanding of how to use them.https://doi.org/10.1002/psp4.12422
collection DOAJ
language English
format Article
sources DOAJ
author Robert J. Bauer
spellingShingle Robert J. Bauer
NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
CPT: Pharmacometrics & Systems Pharmacology
author_facet Robert J. Bauer
author_sort Robert J. Bauer
title NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
title_short NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
title_full NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
title_fullStr NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
title_full_unstemmed NONMEM Tutorial Part II: Estimation Methods and Advanced Examples
title_sort nonmem tutorial part ii: estimation methods and advanced examples
publisher Wiley
series CPT: Pharmacometrics & Systems Pharmacology
issn 2163-8306
publishDate 2019-08-01
description In this second tutorial on NONMEM, the examples of typical pharmacokinetic/pharmacodynamic modeling problems that occur in the pharmaceutical field will be presented, which the reader can use as a template for his or her own modeling endeavors. Each of the problems presented is challenging in some way, and the logic behind setting up each problem is discussed. Logical concepts of the problem itself as well as the technical aspect of how to set it up in NONMEM are described and demonstrated. The concepts behind the various estimation algorithms will first be described to allow the user a better understanding of how to use them.
url https://doi.org/10.1002/psp4.12422
work_keys_str_mv AT robertjbauer nonmemtutorialpartiiestimationmethodsandadvancedexamples
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