Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells
A series of new derivatives (<strong>5</strong>–<strong>29</strong>) of marine-derived bostrycin (<strong>1</strong>) were synthesized. The <em>in vitro</em> cytotoxic activities of all co...
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2012-04-01
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doaj-254fc18540854f818eb59a5cfe09d4002020-11-24T23:17:16ZengMDPI AGMarine Drugs1660-33972012-04-0110493295210.3390/md10040932Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor CellsZhigang SheXun ZhuMengfeng LiShengping ChenYongcheng LinLan LiuJia LiJueheng WuLili ZhongYuhua LongHong ChenA series of new derivatives (<strong>5</strong>–<strong>29</strong>) of marine-derived bostrycin (<strong>1</strong>) were synthesized. The <em>in vitro</em> cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds <strong>7</strong>, <strong>8</strong>, <strong>22</strong>, <strong>23</strong>, <strong>25</strong>, <strong>28</strong> and <strong>29</strong><strong> </strong>of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data.http://www.mdpi.com/1660-3397/10/4/932bostrycinsynthesisantitumorderivativesstructure-activity relationship |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhigang She Xun Zhu Mengfeng Li Shengping Chen Yongcheng Lin Lan Liu Jia Li Jueheng Wu Lili Zhong Yuhua Long Hong Chen |
spellingShingle |
Zhigang She Xun Zhu Mengfeng Li Shengping Chen Yongcheng Lin Lan Liu Jia Li Jueheng Wu Lili Zhong Yuhua Long Hong Chen Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells Marine Drugs bostrycin synthesis antitumor derivatives structure-activity relationship |
author_facet |
Zhigang She Xun Zhu Mengfeng Li Shengping Chen Yongcheng Lin Lan Liu Jia Li Jueheng Wu Lili Zhong Yuhua Long Hong Chen |
author_sort |
Zhigang She |
title |
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells |
title_short |
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells |
title_full |
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells |
title_fullStr |
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells |
title_full_unstemmed |
Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells |
title_sort |
studies on the synthesis of derivatives of marine-derived bostrycin and their structure-activity relationship against tumor cells |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2012-04-01 |
description |
A series of new derivatives (<strong>5</strong>–<strong>29</strong>) of marine-derived bostrycin (<strong>1</strong>) were synthesized. The <em>in vitro</em> cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds <strong>7</strong>, <strong>8</strong>, <strong>22</strong>, <strong>23</strong>, <strong>25</strong>, <strong>28</strong> and <strong>29</strong><strong> </strong>of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. However, these compounds also exhibited cytotoxicity towards MCF-10A cells. The structure-activity relationship (SAR) of bostrycin derivatives was also discussed based on the obtained experimental data. |
topic |
bostrycin synthesis antitumor derivatives structure-activity relationship |
url |
http://www.mdpi.com/1660-3397/10/4/932 |
work_keys_str_mv |
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1725583954167201792 |