Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture
Fish discards and subproducts may represent an important source of raw material, not only for the food industry, but for other different kind of industries, such as the nutraceutical and cosmetic industries. Collagen, which is mainly obtained from animal skins, is an important structural protein in...
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doaj-2550ece94b934f05b60e96e45c0924f82020-11-24T23:46:43ZengMDPI AGMarine Drugs1660-33972018-04-0116514410.3390/md16050144md16050144Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast CultureAna Sanchez0Maria Blanco1Begoña Correa2Ricardo I. Perez-Martin3Carmen G. Sotelo4Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, SpainInstituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, SpainInstituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, SpainInstituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, SpainInstituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36208 Vigo, SpainFish discards and subproducts may represent an important source of raw material, not only for the food industry, but for other different kind of industries, such as the nutraceutical and cosmetic industries. Collagen, which is mainly obtained from animal skins, is an important structural protein in the animal kingdom having many different applications. It is well known that fish skins constitute a significant subproduct in the fishery industry, especially in the case of some species, where fish skins may represent up to 20% of the total body weight of fish. Peptides from collagen hydrolysates have been described to be useful for preventing skin aging and osteoarthritis, however, the mechanism for these biological activities is not well known. Fibroblasts are the main cell types involved in the collagen synthesis, and in the present work, human dermal fibroblasts have been exposed to the treatment of collagen peptides of two different molecular weight ranges. Results show that higher molecular weight collagen peptides produce higher synthesis of collagen type I mRNA and, therefore, it may suggest that prior molecular weight selection may be an important step to maximize the effect of collagen hydrolysates on collagen type I synthesis by dermal fibroblasts.http://www.mdpi.com/1660-3397/16/5/144fish collagencollagen hydrolysatesfibroblasttype I collagen mRNAcommercial collagen hydrolysates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Sanchez Maria Blanco Begoña Correa Ricardo I. Perez-Martin Carmen G. Sotelo |
spellingShingle |
Ana Sanchez Maria Blanco Begoña Correa Ricardo I. Perez-Martin Carmen G. Sotelo Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture Marine Drugs fish collagen collagen hydrolysates fibroblast type I collagen mRNA commercial collagen hydrolysates |
author_facet |
Ana Sanchez Maria Blanco Begoña Correa Ricardo I. Perez-Martin Carmen G. Sotelo |
author_sort |
Ana Sanchez |
title |
Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture |
title_short |
Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture |
title_full |
Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture |
title_fullStr |
Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture |
title_full_unstemmed |
Effect of Fish Collagen Hydrolysates on Type I Collagen mRNA Levels of Human Dermal Fibroblast Culture |
title_sort |
effect of fish collagen hydrolysates on type i collagen mrna levels of human dermal fibroblast culture |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2018-04-01 |
description |
Fish discards and subproducts may represent an important source of raw material, not only for the food industry, but for other different kind of industries, such as the nutraceutical and cosmetic industries. Collagen, which is mainly obtained from animal skins, is an important structural protein in the animal kingdom having many different applications. It is well known that fish skins constitute a significant subproduct in the fishery industry, especially in the case of some species, where fish skins may represent up to 20% of the total body weight of fish. Peptides from collagen hydrolysates have been described to be useful for preventing skin aging and osteoarthritis, however, the mechanism for these biological activities is not well known. Fibroblasts are the main cell types involved in the collagen synthesis, and in the present work, human dermal fibroblasts have been exposed to the treatment of collagen peptides of two different molecular weight ranges. Results show that higher molecular weight collagen peptides produce higher synthesis of collagen type I mRNA and, therefore, it may suggest that prior molecular weight selection may be an important step to maximize the effect of collagen hydrolysates on collagen type I synthesis by dermal fibroblasts. |
topic |
fish collagen collagen hydrolysates fibroblast type I collagen mRNA commercial collagen hydrolysates |
url |
http://www.mdpi.com/1660-3397/16/5/144 |
work_keys_str_mv |
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