Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galec...

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Main Authors:	Sandra M. Blois, Gabriela Dveksler, Gerardo R. Vasta, Nancy Freitag, Véronique Blanchard, Gabriela Barrientos
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-05-01
Series:	Frontiers in Immunology
Subjects:	galectins pregnancy placentation glycans preeclampsia
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01166/full

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record_format	Article
spelling	doaj-256b13cf315740d09dda9c241a4531672020-11-25T01:36:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-05-011010.3389/fimmu.2019.01166454918Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding ProteinsSandra M. Blois0Sandra M. Blois1Gabriela Dveksler2Gerardo R. Vasta3Nancy Freitag4Véronique Blanchard5Gabriela Barrientos6Reproductive Medicine Research Group, Division of General Internal and Psychosomatic Medicine, Berlin Institute of Health, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GermanyExperimental and Clinical Research Center, a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and Charité - Universitätsmedizin Berlin, Berlin, GermanyDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesDepartment of Microbiology and Immunology, Institute of Marine and Environmental Technology, University of Maryland School of Medicine, UMB, Baltimore, MD, United StatesExperimental and Clinical Research Center, a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, and Charité - Universitätsmedizin Berlin, Berlin, GermanyBerlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, GermanyLaboratory of Experimental Medicine, Hospital Alemán, School of Medicine, University of Buenos Aires, CONICET, Buenos Aires, ArgentinaGalectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.https://www.frontiersin.org/article/10.3389/fimmu.2019.01166/fullgalectinspregnancyplacentationglycanspreeclampsia
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sandra M. Blois Sandra M. Blois Gabriela Dveksler Gerardo R. Vasta Nancy Freitag Véronique Blanchard Gabriela Barrientos
spellingShingle	Sandra M. Blois Sandra M. Blois Gabriela Dveksler Gerardo R. Vasta Nancy Freitag Véronique Blanchard Gabriela Barrientos Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins Frontiers in Immunology galectins pregnancy placentation glycans preeclampsia
author_facet	Sandra M. Blois Sandra M. Blois Gabriela Dveksler Gerardo R. Vasta Nancy Freitag Véronique Blanchard Gabriela Barrientos
author_sort	Sandra M. Blois
title	Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_short	Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_full	Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_fullStr	Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_full_unstemmed	Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins
title_sort	pregnancy galectinology: insights into a complex network of glycan binding proteins
publisher	Frontiers Media S.A.
series	Frontiers in Immunology
issn	1664-3224
publishDate	2019-05-01
description	Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.
topic	galectins pregnancy placentation glycans preeclampsia
url	https://www.frontiersin.org/article/10.3389/fimmu.2019.01166/full
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Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

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