Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease
Introduction: Previous studies have found associations between grey matter atrophy and white matter hyperintensities (WMH) of vascular origin with cognitive and motor deficits in Parkinson’s disease (PD). Here we investigate these relationships in a sample of PD patients and age-matched healthy cont...
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doaj-256c1994ddcc40a582e77e04a45cc6032020-11-25T03:04:41ZengElsevierNeuroImage: Clinical2213-15822020-01-0127102353Cognitive and motor correlates of grey and white matter pathology in Parkinson’s diseaseMahsa Dadar0Myrlene Gee1Ashfaq Shuaib2Simon Duchesne3Richard Camicioli4Department of Radiology and Nuclear Medicine, Faculty of Medicine, Laval University, Canada; Corresponding author at: Cervo Brain Research Centre, 2601 Chemin de la Canardière, Québec G1J 2G3, CanadaDepartment of Medicine, Division of Neurology, University of Alberta, CanadaDepartment of Medicine, Division of Neurology, University of Alberta, CanadaDepartment of Radiology and Nuclear Medicine, Faculty of Medicine, Laval University, CanadaDepartment of Medicine, Division of Neurology, University of Alberta, CanadaIntroduction: Previous studies have found associations between grey matter atrophy and white matter hyperintensities (WMH) of vascular origin with cognitive and motor deficits in Parkinson’s disease (PD). Here we investigate these relationships in a sample of PD patients and age-matched healthy controls. Methods: Data included 50 PD patients and 45 age-matched controls with T1-weighted and FLAIR scans at baseline, 18-months, and 36-months follow-up. Deformation-based morphometry was used to measure grey matter atrophy. SNIPE (Scoring by Nonlocal Image Patch Estimator) was used to measure Alzheimer’s disease-like textural patterns in the hippocampi. WMHs were segmented using T1-weighted and FLAIR images. The relationship between MRI features and clinical scores was assessed using mixed-effects models. The motor subscore of the Unified Parkinson's Disease Rating Scale (UPDRSIII), number of steps in a walking trial, and Dementia Rating Scale (DRS) were used respectively as measures of motor function, gait, and cognition. Results: Substantia nigra atrophy was significantly associated with motor deficits, with a greater impact in PDs (p < 0.05). Hippocampal SNIPE scores were associated with cognitve decline in both PD and controls (p < 0.01). WMH burden was significantly associated with cognitive decline and increased motor deficits in the PD group, and gait deficits in both PD and controls (p < 0.03). Conclusion: While substantia nigra atrophy and WMH burden were significantly associated with additional motor deficits, WMH burden and hippocampal atrophy were associated with cognitive deficits in PD patients. These results suggest an additive contribution of both grey and white matter damage to the motor and cognitive deficits in PD.http://www.sciencedirect.com/science/article/pii/S221315822030190XParkinson’s diseaseWhite matter hyperintensitiesGrey matter atrophyDeformation based morphometryScoring by Nonlocal Image Patch Estimator |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahsa Dadar Myrlene Gee Ashfaq Shuaib Simon Duchesne Richard Camicioli |
spellingShingle |
Mahsa Dadar Myrlene Gee Ashfaq Shuaib Simon Duchesne Richard Camicioli Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease NeuroImage: Clinical Parkinson’s disease White matter hyperintensities Grey matter atrophy Deformation based morphometry Scoring by Nonlocal Image Patch Estimator |
author_facet |
Mahsa Dadar Myrlene Gee Ashfaq Shuaib Simon Duchesne Richard Camicioli |
author_sort |
Mahsa Dadar |
title |
Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease |
title_short |
Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease |
title_full |
Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease |
title_fullStr |
Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease |
title_full_unstemmed |
Cognitive and motor correlates of grey and white matter pathology in Parkinson’s disease |
title_sort |
cognitive and motor correlates of grey and white matter pathology in parkinson’s disease |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2020-01-01 |
description |
Introduction: Previous studies have found associations between grey matter atrophy and white matter hyperintensities (WMH) of vascular origin with cognitive and motor deficits in Parkinson’s disease (PD). Here we investigate these relationships in a sample of PD patients and age-matched healthy controls. Methods: Data included 50 PD patients and 45 age-matched controls with T1-weighted and FLAIR scans at baseline, 18-months, and 36-months follow-up. Deformation-based morphometry was used to measure grey matter atrophy. SNIPE (Scoring by Nonlocal Image Patch Estimator) was used to measure Alzheimer’s disease-like textural patterns in the hippocampi. WMHs were segmented using T1-weighted and FLAIR images. The relationship between MRI features and clinical scores was assessed using mixed-effects models. The motor subscore of the Unified Parkinson's Disease Rating Scale (UPDRSIII), number of steps in a walking trial, and Dementia Rating Scale (DRS) were used respectively as measures of motor function, gait, and cognition. Results: Substantia nigra atrophy was significantly associated with motor deficits, with a greater impact in PDs (p < 0.05). Hippocampal SNIPE scores were associated with cognitve decline in both PD and controls (p < 0.01). WMH burden was significantly associated with cognitive decline and increased motor deficits in the PD group, and gait deficits in both PD and controls (p < 0.03). Conclusion: While substantia nigra atrophy and WMH burden were significantly associated with additional motor deficits, WMH burden and hippocampal atrophy were associated with cognitive deficits in PD patients. These results suggest an additive contribution of both grey and white matter damage to the motor and cognitive deficits in PD. |
topic |
Parkinson’s disease White matter hyperintensities Grey matter atrophy Deformation based morphometry Scoring by Nonlocal Image Patch Estimator |
url |
http://www.sciencedirect.com/science/article/pii/S221315822030190X |
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