Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease

Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease

Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson’s disease. Recent research indicates that angiotensin-(1–7) plays a crucial role in several neurodegenerative disorders, includ...

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Bibliographic Details
Main Authors: Qing Gao, Rui Chen, Liang Wu, Qing Huang, Xi-Xi Wang, You-Yong Tian, Ying-Dong Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
α-synuclein; apoptosis; autophagy; dopaminergic neuron; lewy bodies; neurodegenerative diseases; parkinson’s disease; renin-angiotensin system; rotenone; substantia nigra
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=5;spage=1138;epage=1145;aulast=Gao

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