Astrocyte Function Is Affected by Aging and Not Alzheimer’s Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice

Astrocyte Function Is Affected by Aging and Not Alzheimer’s Disease: A Preliminary Investigation in Hippocampi of 3xTg-AD Mice

Old age is a risk factor for Alzheimer’s disease (AD), which is characterized by hippocampal impairment together with substantial changes in glial cell functions. Are these alterations due to the disease progression or are they a consequence of aging? To start addressing this issue, we studied the e...

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Bibliographic Details
Main Authors: Maria Rosanna Bronzuoli, Roberta Facchinetti, Marta Valenza, Tommaso Cassano, Luca Steardo, Caterina Scuderi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
aging
Alzheimer’s disease
3×Tg-AD mouse
astrocyte
connexin-43
AQP4
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00644/full

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