MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL
The objective of this research was to synthesize new compounds with potential biological activity from readily accessed natural products. Eugenol has been reported to posses antioxidant and anticancer properties and was prepared by extracting from clove buds with dichloromethane and followed by isol...
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doaj-257dd292f9ee436aada8e1e96a0b58772020-11-24T23:52:44ZengUniversitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782013-08-0113218118410.22146/ijc.2130314401MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OILI Made Sudarma0Emmy Yuanita1I Wayan Suana2Chemistry Laboratory, Faculty of Science, University of Mataram, Jl. Majapahit 62 Mataram, West Nusa Tenggara, 83125Chemistry Laboratory, Faculty of Science, University of Mataram, Jl. Majapahit 62 Mataram, West Nusa Tenggara, 83125Chemistry Laboratory, Faculty of Science, University of Mataram, Jl. Majapahit 62 Mataram, West Nusa Tenggara, 83125The objective of this research was to synthesize new compounds with potential biological activity from readily accessed natural products. Eugenol has been reported to posses antioxidant and anticancer properties and was prepared by extracting from clove buds with dichloromethane and followed by isolation using column chromatography to afford pure eugenol (73%). In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. The main aim of this preliminary research was to transform eugenol to become sulfonic derivative. Eugenol was transformed to its sulfonic derivative in moderate yield (64%) by treatment with chlorosulfuric acid which undergoes Markovnikov addition. This product was rapidly confirmed by GC-MS and NMR analyses. Selective inhibition was performed by cyclic sulfonic ester derivative which could inhibit Eschericia coli and Staphylococcus aureus but not for Bacillus cereus.https://jurnal.ugm.ac.id/ijc/article/view/21303Markovnikov additionchlorosulfuric acideugenol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
I Made Sudarma Emmy Yuanita I Wayan Suana |
spellingShingle |
I Made Sudarma Emmy Yuanita I Wayan Suana MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL Indonesian Journal of Chemistry Markovnikov addition chlorosulfuric acid eugenol |
author_facet |
I Made Sudarma Emmy Yuanita I Wayan Suana |
author_sort |
I Made Sudarma |
title |
MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL |
title_short |
MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL |
title_full |
MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL |
title_fullStr |
MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL |
title_full_unstemmed |
MARKOVNIKOV ADDITION OF CHLOROSULFURIC ACID TO EUGENOL ISOLATED FROM CLOVE OIL |
title_sort |
markovnikov addition of chlorosulfuric acid to eugenol isolated from clove oil |
publisher |
Universitas Gadjah Mada |
series |
Indonesian Journal of Chemistry |
issn |
1411-9420 2460-1578 |
publishDate |
2013-08-01 |
description |
The objective of this research was to synthesize new compounds with potential biological activity from readily accessed natural products. Eugenol has been reported to posses antioxidant and anticancer properties and was prepared by extracting from clove buds with dichloromethane and followed by isolation using column chromatography to afford pure eugenol (73%). In an attempt to enhance intrinsic activity of this natural compound, some derivatives were possible to synthesize. The main aim of this preliminary research was to transform eugenol to become sulfonic derivative. Eugenol was transformed to its sulfonic derivative in moderate yield (64%) by treatment with chlorosulfuric acid which undergoes Markovnikov addition. This product was rapidly confirmed by GC-MS and NMR analyses. Selective inhibition was performed by cyclic sulfonic ester derivative which could inhibit Eschericia coli and Staphylococcus aureus but not for Bacillus cereus. |
topic |
Markovnikov addition chlorosulfuric acid eugenol |
url |
https://jurnal.ugm.ac.id/ijc/article/view/21303 |
work_keys_str_mv |
AT imadesudarma markovnikovadditionofchlorosulfuricacidtoeugenolisolatedfromcloveoil AT emmyyuanita markovnikovadditionofchlorosulfuricacidtoeugenolisolatedfromcloveoil AT iwayansuana markovnikovadditionofchlorosulfuricacidtoeugenolisolatedfromcloveoil |
_version_ |
1716259443929251840 |