Potential of Novel EPO Derivatives in Limb Ischemia

Potential of Novel EPO Derivatives in Limb Ischemia

Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and...

Full description

Bibliographic Details
Main Authors: Dhiraj Joshi, Janice Tsui, Rebekah Yu, Xu Shiwen, Sadasivam Selvakumar, David J. Abraham, Daryll M. Baker
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Cardiology Research and Practice
Online Access:http://dx.doi.org/10.1155/2012/213785
id doaj-25827942427d4268bb33d6fb5b8cc237
record_format Article
spelling doaj-25827942427d4268bb33d6fb5b8cc2372020-11-25T00:25:32ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/213785213785Potential of Novel EPO Derivatives in Limb IschemiaDhiraj Joshi0Janice Tsui1Rebekah Yu2Xu Shiwen3Sadasivam Selvakumar4David J. Abraham5Daryll M. Baker6Vascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKCentre for Rheumatology, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKCentre for Rheumatology, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKErythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.http://dx.doi.org/10.1155/2012/213785
collection DOAJ
language English
format Article
sources DOAJ
author Dhiraj Joshi
Janice Tsui
Rebekah Yu
Xu Shiwen
Sadasivam Selvakumar
David J. Abraham
Daryll M. Baker
spellingShingle Dhiraj Joshi
Janice Tsui
Rebekah Yu
Xu Shiwen
Sadasivam Selvakumar
David J. Abraham
Daryll M. Baker
Potential of Novel EPO Derivatives in Limb Ischemia
Cardiology Research and Practice
author_facet Dhiraj Joshi
Janice Tsui
Rebekah Yu
Xu Shiwen
Sadasivam Selvakumar
David J. Abraham
Daryll M. Baker
author_sort Dhiraj Joshi
title Potential of Novel EPO Derivatives in Limb Ischemia
title_short Potential of Novel EPO Derivatives in Limb Ischemia
title_full Potential of Novel EPO Derivatives in Limb Ischemia
title_fullStr Potential of Novel EPO Derivatives in Limb Ischemia
title_full_unstemmed Potential of Novel EPO Derivatives in Limb Ischemia
title_sort potential of novel epo derivatives in limb ischemia
publisher Hindawi Limited
series Cardiology Research and Practice
issn 2090-8016
2090-0597
publishDate 2012-01-01
description Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.
url http://dx.doi.org/10.1155/2012/213785
work_keys_str_mv AT dhirajjoshi potentialofnovelepoderivativesinlimbischemia
AT janicetsui potentialofnovelepoderivativesinlimbischemia
AT rebekahyu potentialofnovelepoderivativesinlimbischemia
AT xushiwen potentialofnovelepoderivativesinlimbischemia
AT sadasivamselvakumar potentialofnovelepoderivativesinlimbischemia
AT davidjabraham potentialofnovelepoderivativesinlimbischemia
AT daryllmbaker potentialofnovelepoderivativesinlimbischemia
_version_ 1725348421709070336

Similar Items