Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men
Background: Peripheral quantitative computed tomography (pQCT) can provide information complementary to dual x-ray absorptiometry (DXA), however, there is sparse normative data to enable meaningful clinical interpretation and comparison. This study aimed to develop age-stratified normative data for...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-12-01
|
Series: | Bone Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187221003636 |
id |
doaj-258b3c97d18b45f082951057f44d311c |
---|---|
record_format |
Article |
spelling |
doaj-258b3c97d18b45f082951057f44d311c2021-07-23T04:49:52ZengElsevierBone Reports2352-18722021-12-0115101107Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian menKara B. Anderson0Monica C. Tembo1Sophia X. Sui2Natalie K. Hyde3Pamela G. Rufus4Julie A. Pasco5Mark A. Kotowicz6Kara L. Holloway-Kew7Deakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, Australia; Corresponding author at: Epi-Centre for Healthy Ageing (ECHA), IMPACT Institute, Deakin University, PO Box 281 (Barwon Health), Geelong, VIC 3220, Australia.Deakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, Australia; Barwon Health, Geelong, VIC, Australia; Department of Medicine – Western Health, The University of Melbourne, St Albans, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Prahran, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, Australia; Barwon Health, Geelong, VIC, Australia; Department of Medicine – Western Health, The University of Melbourne, St Albans, VIC, AustraliaDeakin University, IMPACT (Institute for Mental and Physical Health and Clinical Translation), Geelong, VIC, AustraliaBackground: Peripheral quantitative computed tomography (pQCT) can provide information complementary to dual x-ray absorptiometry (DXA), however, there is sparse normative data to enable meaningful clinical interpretation and comparison. This study aimed to develop age-stratified normative data for pQCT-derived bone parameters in Australian men. Methods: Participants were men (n = 508, age 33-96 yr) from the Geelong Osteoporosis Study. Bone parameters at 4% (n = 469) and 66% (n = 436) of radial length, and 4% (n = 449) and 66% (n = 438) of tibial length were acquired using pQCT (XCT 2000, Stratec Medizintechnik, Pforzheim, Germany). Best models of age, height and weight for each parameter were developed and where parameters exhibited variation with age, age decade mean (±SD) values were determined. Scatterplots were used to visualise the relationships between each of the parameters and age, height and weight. Results: Thirteen parameters at tibial and radial sites were correlated with age, height and weight, allowing for their inclusion in multiple linear regression models. A positive association with age was found for total area of the tibia or radius (as appropriate) (mm2) at all sites, trabecular bone area (mm2) at 4% sites, and total bone area (both long bones) (mm2) at 66% sites. A negative association with age was found for cortical density (mg/cm3) and cortical thickness (mm) at both radial and tibial 66% sites, but total density (mg/cm3) at the 66% radial site and total cortical density of both long bones (mg/cm3) at the 66% tibial site only. Conclusion: This study presents normative data for pQCT-derived bone parameters and describes age related associations in a number of these variables. Broadly, parameters of bone area were positively associated with age, whereas parameters associated with bone density and structure were negatively associated with age. These data have the potential to be used in clinical settings when assessing age-related decline in bone health. Mini abstract: Normative data for pQCT parameters in Australian men are presented, adjusted for age, height and weight.http://www.sciencedirect.com/science/article/pii/S2352187221003636Peripheral quantitative computed tomography (pQCT)Normative dataMenReference values |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kara B. Anderson Monica C. Tembo Sophia X. Sui Natalie K. Hyde Pamela G. Rufus Julie A. Pasco Mark A. Kotowicz Kara L. Holloway-Kew |
spellingShingle |
Kara B. Anderson Monica C. Tembo Sophia X. Sui Natalie K. Hyde Pamela G. Rufus Julie A. Pasco Mark A. Kotowicz Kara L. Holloway-Kew Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men Bone Reports Peripheral quantitative computed tomography (pQCT) Normative data Men Reference values |
author_facet |
Kara B. Anderson Monica C. Tembo Sophia X. Sui Natalie K. Hyde Pamela G. Rufus Julie A. Pasco Mark A. Kotowicz Kara L. Holloway-Kew |
author_sort |
Kara B. Anderson |
title |
Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men |
title_short |
Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men |
title_full |
Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men |
title_fullStr |
Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men |
title_full_unstemmed |
Normative data for peripheral quantitative computed tomography (pQCT) bone parameters in Australian men |
title_sort |
normative data for peripheral quantitative computed tomography (pqct) bone parameters in australian men |
publisher |
Elsevier |
series |
Bone Reports |
issn |
2352-1872 |
publishDate |
2021-12-01 |
description |
Background: Peripheral quantitative computed tomography (pQCT) can provide information complementary to dual x-ray absorptiometry (DXA), however, there is sparse normative data to enable meaningful clinical interpretation and comparison. This study aimed to develop age-stratified normative data for pQCT-derived bone parameters in Australian men. Methods: Participants were men (n = 508, age 33-96 yr) from the Geelong Osteoporosis Study. Bone parameters at 4% (n = 469) and 66% (n = 436) of radial length, and 4% (n = 449) and 66% (n = 438) of tibial length were acquired using pQCT (XCT 2000, Stratec Medizintechnik, Pforzheim, Germany). Best models of age, height and weight for each parameter were developed and where parameters exhibited variation with age, age decade mean (±SD) values were determined. Scatterplots were used to visualise the relationships between each of the parameters and age, height and weight. Results: Thirteen parameters at tibial and radial sites were correlated with age, height and weight, allowing for their inclusion in multiple linear regression models. A positive association with age was found for total area of the tibia or radius (as appropriate) (mm2) at all sites, trabecular bone area (mm2) at 4% sites, and total bone area (both long bones) (mm2) at 66% sites. A negative association with age was found for cortical density (mg/cm3) and cortical thickness (mm) at both radial and tibial 66% sites, but total density (mg/cm3) at the 66% radial site and total cortical density of both long bones (mg/cm3) at the 66% tibial site only. Conclusion: This study presents normative data for pQCT-derived bone parameters and describes age related associations in a number of these variables. Broadly, parameters of bone area were positively associated with age, whereas parameters associated with bone density and structure were negatively associated with age. These data have the potential to be used in clinical settings when assessing age-related decline in bone health. Mini abstract: Normative data for pQCT parameters in Australian men are presented, adjusted for age, height and weight. |
topic |
Peripheral quantitative computed tomography (pQCT) Normative data Men Reference values |
url |
http://www.sciencedirect.com/science/article/pii/S2352187221003636 |
work_keys_str_mv |
AT karabanderson normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT monicactembo normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT sophiaxsui normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT nataliekhyde normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT pamelagrufus normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT julieapasco normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT markakotowicz normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen AT karalhollowaykew normativedataforperipheralquantitativecomputedtomographypqctboneparametersinaustralianmen |
_version_ |
1721290472012382208 |