Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia
Objective: Preeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the o...
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Bioscientifica
2017-10-01
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doaj-258fe92d82254b209a94155a6161a0e72020-11-25T00:58:14ZengBioscientificaEndocrine Connections2049-36142049-36142017-10-016859560010.1530/EC-17-0130Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsiaJian Ding0Yan Kang1Yuqin Fan2Qi Chen3Department of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China; Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, ChinaDepartment of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China; Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, ChinaDepartment of Obstetrics and Gynecology, Maternal and Child Health Care Hospital of Shandong Province, Jinan, Shandong Province, China; Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, ChinaDepartment of Obstetrics and Gynecology, Zoucheng People’s Hospital, Zoucheng, Shandong Province, ChinaObjective: Preeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the outcome of treatment combining oral nifedipine (NIFE) and RESV against PE. Design and methods: Using a randomized group assignment, 400 PE patients were enrolled and received oral treatments of either NIFE + RESV or NIFE + placebo. Primary endpoints were defined as time to control blood pressure and time before a new hypertensive crisis. Secondary endpoints were defined as the number of doses needed to control blood pressure, maternal and neonatal adverse effects. Results: Compared with the NIFE + placebo group, the time needed to control blood pressure was significantly reduced in NIFE + RESV group, while time before a new hypertensive crisis was greatly delayed in NIFE + RESV group. The number of treatment doses needed to control blood pressure was also categorically lower in NIFE + RESV group. No differences in maternal or neonatal adverse effects were observed between the two treatment groups. Conclusion: Our data support the potential of RESV as a safe and effective adjuvant of oral NIFE to attenuate hypertensive symptoms among PE patients.http://www.endocrineconnections.com/content/6/8/595.fullpreeclampsiaresveratrolnifedipinehypertensionpregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jian Ding Yan Kang Yuqin Fan Qi Chen |
spellingShingle |
Jian Ding Yan Kang Yuqin Fan Qi Chen Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia Endocrine Connections preeclampsia resveratrol nifedipine hypertension pregnancy |
author_facet |
Jian Ding Yan Kang Yuqin Fan Qi Chen |
author_sort |
Jian Ding |
title |
Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
title_short |
Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
title_full |
Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
title_fullStr |
Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
title_full_unstemmed |
Efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
title_sort |
efficacy of resveratrol to supplement oral nifedipine treatment in pregnancy-induced preeclampsia |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2017-10-01 |
description |
Objective: Preeclampsia (PE) is a complication affecting pregnant women worldwide, which usually manifests as severe maternal hypertension. Resveratrol (RESV), a naturally existing polyphenol, is known to exhibit beneficial effects in cardiovascular disease including hypertension. We evaluated the outcome of treatment combining oral nifedipine (NIFE) and RESV against PE.
Design and methods: Using a randomized group assignment, 400 PE patients were enrolled and received oral treatments of either NIFE + RESV or NIFE + placebo. Primary endpoints were defined as time to control blood pressure and time before a new hypertensive crisis. Secondary endpoints were defined as the number of doses needed to control blood pressure, maternal and neonatal adverse effects.
Results: Compared with the NIFE + placebo group, the time needed to control blood pressure was significantly reduced in NIFE + RESV group, while time before a new hypertensive crisis was greatly delayed in NIFE + RESV group. The number of treatment doses needed to control blood pressure was also categorically lower in NIFE + RESV group. No differences in maternal or neonatal adverse effects were observed between the two treatment groups.
Conclusion: Our data support the potential of RESV as a safe and effective adjuvant of oral NIFE to attenuate hypertensive symptoms among PE patients. |
topic |
preeclampsia resveratrol nifedipine hypertension pregnancy |
url |
http://www.endocrineconnections.com/content/6/8/595.full |
work_keys_str_mv |
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