New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel

Transcription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzyme surface that leads to its active center. Despite...

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Main Authors:	Nikolay Zenkin, Yulia Yuzenkova
Format:	Article
Language:	English
Published:	MDPI AG 2015-06-01
Series:	Biomolecules
Subjects:	RNA polymerase secondary channel transcription factors DksA Gre transcription fidelity transcription processivity transcription-replication conflicts
Online Access:	http://www.mdpi.com/2218-273X/5/3/1195

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spelling	doaj-258feeb8e9b640839cd5cc7179a290432020-11-24T22:44:54ZengMDPI AGBiomolecules2218-273X2015-06-01531195120910.3390/biom5031195biom5031195New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary ChannelNikolay Zenkin0Yulia Yuzenkova1Center for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UKCenter for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UKTranscription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzyme surface that leads to its active center. Despite investigation for several years, the activities and in vivo roles of some of these factors remain obscure. Here, we review the recent progress in understanding the functions of the secondary channel binding factors in bacteria. In particular, we highlight the surprising role of global regulator DksA in fidelity of RNA synthesis and the resolution of RNA polymerase traffic jams by the Gre factor. These findings indicate a potential link between transcription fidelity and collisions of the transcription and replication machineries.http://www.mdpi.com/2218-273X/5/3/1195RNA polymerasesecondary channeltranscription factorsDksAGretranscription fidelitytranscription processivitytranscription-replication conflicts
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nikolay Zenkin Yulia Yuzenkova
spellingShingle	Nikolay Zenkin Yulia Yuzenkova New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel Biomolecules RNA polymerase secondary channel transcription factors DksA Gre transcription fidelity transcription processivity transcription-replication conflicts
author_facet	Nikolay Zenkin Yulia Yuzenkova
author_sort	Nikolay Zenkin
title	New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
title_short	New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
title_full	New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
title_fullStr	New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
title_full_unstemmed	New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel
title_sort	new insights into the functions of transcription factors that bind the rna polymerase secondary channel
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2015-06-01
description	Transcription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzyme surface that leads to its active center. Despite investigation for several years, the activities and in vivo roles of some of these factors remain obscure. Here, we review the recent progress in understanding the functions of the secondary channel binding factors in bacteria. In particular, we highlight the surprising role of global regulator DksA in fidelity of RNA synthesis and the resolution of RNA polymerase traffic jams by the Gre factor. These findings indicate a potential link between transcription fidelity and collisions of the transcription and replication machineries.
topic	RNA polymerase secondary channel transcription factors DksA Gre transcription fidelity transcription processivity transcription-replication conflicts
url	http://www.mdpi.com/2218-273X/5/3/1195
work_keys_str_mv	AT nikolayzenkin newinsightsintothefunctionsoftranscriptionfactorsthatbindthernapolymerasesecondarychannel AT yuliayuzenkova newinsightsintothefunctionsoftranscriptionfactorsthatbindthernapolymerasesecondarychannel
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New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel

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