Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort
Background: Pregnant women are ubiquitously exposed to organic solvents, such as glycol ethers. Several studies suggest potential developmental neurotoxicity following exposure to glycol ethers with a lack of clarity of possible brain mechanisms. Objectives: We investigated the association between u...
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Format: | Article |
Language: | English |
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Elsevier
2019-12-01
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Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019301825 |
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doaj-25a8d2d787f1433b9bf118130737a6f8 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne-Claire Binter Elise Bannier Grégory Simon Dave Saint-Amour Jean-Christophe Ferré Christian Barillot Christine Monfort Sylvaine Cordier Cécile Chevrier Fabienne Pelé |
spellingShingle |
Anne-Claire Binter Elise Bannier Grégory Simon Dave Saint-Amour Jean-Christophe Ferré Christian Barillot Christine Monfort Sylvaine Cordier Cécile Chevrier Fabienne Pelé Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort Environment International |
author_facet |
Anne-Claire Binter Elise Bannier Grégory Simon Dave Saint-Amour Jean-Christophe Ferré Christian Barillot Christine Monfort Sylvaine Cordier Cécile Chevrier Fabienne Pelé |
author_sort |
Anne-Claire Binter |
title |
Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort |
title_short |
Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort |
title_full |
Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort |
title_fullStr |
Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort |
title_full_unstemmed |
Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort |
title_sort |
prenatal exposure to glycol ethers and motor inhibition function evaluated by functional mri at the age of 10 to 12 years in the pelagie mother-child cohort |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2019-12-01 |
description |
Background: Pregnant women are ubiquitously exposed to organic solvents, such as glycol ethers. Several studies suggest potential developmental neurotoxicity following exposure to glycol ethers with a lack of clarity of possible brain mechanisms. Objectives: We investigated the association between urinary levels of glycol ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods: Exposure to glycol ethers was assessed by measuring six metabolites in urine (<19 weeks of gestation) of 73 pregnant women of the PELAGIE mother-child cohort (France). Maternal urinary levels were classified as low, medium, or high. Children underwent functional magnetic resonance imaging (fMRI) examinations during which motor inhibition function was assessed with a Go/No-Go task. Analyses were performed using linear regression for task performance and generalized linear mixed-effect models for brain activation, FWER-corrected for multiple testing at the spatial cluster level. Confounders were considered by restriction and a priori adjustment. Results: Higher maternal butoxyacetic acid (BAA) urinary concentrations were associated with poorer child performance (β = −1.1; 95% CI: −1.9, −0.2 for high vs low). There was also a trend for ethoxyacetic acid (EAA) towards poorer performance (β = −0.3; 95% CI: −0.7, 0.01). Considering inhibition demand, there were increased activity in occipital regions in association with moderate EAA (left cuneus) and moderate methoxyacetic acid (MAA) (right precuneus). When children succeeded to inhibit, high ethoxyethoxyacetic acid (EEAA) and moderate phenoxyacetic acid (PhAA) levels were associated with differential activity in frontal cortex, involved in inhibition network. Discussion: Prenatal urinary levels of two glycol ether metabolites were associated with poorer Go/No-Go task performance. Differential activations were observed in the brain motor inhibition network in relation with successful inhibition, but not with cognitive demand. Nevertheless, there is no consistence between performance indicators and cerebral activity results. Other studies are highly necessary given the ubiquity of glycol ether exposure. |
url |
http://www.sciencedirect.com/science/article/pii/S0160412019301825 |
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doaj-25a8d2d787f1433b9bf118130737a6f82020-11-25T01:18:44ZengElsevierEnvironment International0160-41202019-12-01133Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohortAnne-Claire Binter0Elise Bannier1Grégory Simon2Dave Saint-Amour3Jean-Christophe Ferré4Christian Barillot5Christine Monfort6Sylvaine Cordier7Cécile Chevrier8Fabienne Pelé9Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France; Corresponding author at: Inserm UMR 1085 Irset, 9 Avenue du Pr. Léon Bernard, 35000 Rennes, France.Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé) - ERL U 1228, F-35000 Rennes, France; CHU Rennes, Radiology Department, Rennes, FranceISTS EA 7466, University of Caen Normandie, Caen, FranceDepartment of Psychology, Université du Québec à Montréal, Montréal, CanadaUniv Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé) - ERL U 1228, F-35000 Rennes, France; CHU Rennes, Radiology Department, Rennes, FranceUniv Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES (Vision, action et gestion des informations en santé) - ERL U 1228, F-35000 Rennes, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France; Univ Rennes, Inserm, CIC 1414, Rennes, FranceBackground: Pregnant women are ubiquitously exposed to organic solvents, such as glycol ethers. Several studies suggest potential developmental neurotoxicity following exposure to glycol ethers with a lack of clarity of possible brain mechanisms. Objectives: We investigated the association between urinary levels of glycol ethers of women during early pregnancy and motor inhibition function of their 10- to 12-year-old children by behavioral assessment and brain imaging. Methods: Exposure to glycol ethers was assessed by measuring six metabolites in urine (<19 weeks of gestation) of 73 pregnant women of the PELAGIE mother-child cohort (France). Maternal urinary levels were classified as low, medium, or high. Children underwent functional magnetic resonance imaging (fMRI) examinations during which motor inhibition function was assessed with a Go/No-Go task. Analyses were performed using linear regression for task performance and generalized linear mixed-effect models for brain activation, FWER-corrected for multiple testing at the spatial cluster level. Confounders were considered by restriction and a priori adjustment. Results: Higher maternal butoxyacetic acid (BAA) urinary concentrations were associated with poorer child performance (β = −1.1; 95% CI: −1.9, −0.2 for high vs low). There was also a trend for ethoxyacetic acid (EAA) towards poorer performance (β = −0.3; 95% CI: −0.7, 0.01). Considering inhibition demand, there were increased activity in occipital regions in association with moderate EAA (left cuneus) and moderate methoxyacetic acid (MAA) (right precuneus). When children succeeded to inhibit, high ethoxyethoxyacetic acid (EEAA) and moderate phenoxyacetic acid (PhAA) levels were associated with differential activity in frontal cortex, involved in inhibition network. Discussion: Prenatal urinary levels of two glycol ether metabolites were associated with poorer Go/No-Go task performance. Differential activations were observed in the brain motor inhibition network in relation with successful inhibition, but not with cognitive demand. Nevertheless, there is no consistence between performance indicators and cerebral activity results. Other studies are highly necessary given the ubiquity of glycol ether exposure.http://www.sciencedirect.com/science/article/pii/S0160412019301825 |