Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis
Individuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial lung infection, which contributes to the growing emergence of multidrug resistant (MDR) pathogens isolated. Pathogens such as Pseudomonas aeruginosa that are commonly isolated from individuals with CF are...
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doaj-25b14087df9049ab91f9f1186bd041442021-01-11T05:06:21ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-01-011110.3389/fmicb.2020.593988593988Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic FibrosisRenee N. Ng0Renee N. Ng1Anna S. Tai2Anna S. Tai3Barbara J. Chang4Stephen M. Stick5Stephen M. Stick6Stephen M. Stick7Anthony Kicic8Anthony Kicic9Anthony Kicic10Anthony Kicic11School of Biomedical Sciences, The University of Western Australia, Perth, WA, AustraliaWal-yan Respiratory Research Center, Telethon Kids Institute, The University of Western Australia, Crawley, WA, AustraliaDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, AustraliaInstitute for Respiratory Health, School of Medicine, The University of Western Australia, Perth, WA, AustraliaThe Marshall Center for Infectious Diseases Research and Training, School of Biomedical Sciences, The University of Western Australia, Perth, WA, AustraliaWal-yan Respiratory Research Center, Telethon Kids Institute, The University of Western Australia, Crawley, WA, AustraliaDepartment of Respiratory and Sleep Medicine, Perth Children’s Hospital, Perth, WA, AustraliaCenter for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, The University of Western Australia and Harry Perkins Institute of Medical Research, Perth, WA, AustraliaWal-yan Respiratory Research Center, Telethon Kids Institute, The University of Western Australia, Crawley, WA, AustraliaDepartment of Respiratory and Sleep Medicine, Perth Children’s Hospital, Perth, WA, AustraliaCenter for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, The University of Western Australia and Harry Perkins Institute of Medical Research, Perth, WA, AustraliaOccupation and the Environment, School of Public Health, Curtin University, Perth, WA, AustraliaIndividuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial lung infection, which contributes to the growing emergence of multidrug resistant (MDR) pathogens isolated. Pathogens such as Pseudomonas aeruginosa that are commonly isolated from individuals with CF are armed with an arsenal of protective and virulence mechanisms, complicating eradication and treatment strategies. While translation of phage therapy into standard care for CF has been explored, challenges such as the lack of an appropriate animal model demonstrating safety in vivo exist. In this review, we have discussed and provided some insights in the use of primary airway epithelial cells to represent the mucoenvironment of the CF lungs to demonstrate safety and efficacy of phage therapy. The combination of phage therapy and antimicrobials is gaining attention and has the potential to delay the onset of MDR infections. It is evident that efforts to translate phage therapy into standard clinical practice have gained traction in the past 5 years. Ultimately, collaboration, transparency in data publications and standardized policies are needed for clinical translation.https://www.frontiersin.org/articles/10.3389/fmicb.2020.593988/fullbacteriophagecystic fibrosislung diseasealternative therapyanimal modelsantimicrobials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renee N. Ng Renee N. Ng Anna S. Tai Anna S. Tai Barbara J. Chang Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic |
spellingShingle |
Renee N. Ng Renee N. Ng Anna S. Tai Anna S. Tai Barbara J. Chang Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis Frontiers in Microbiology bacteriophage cystic fibrosis lung disease alternative therapy animal models antimicrobials |
author_facet |
Renee N. Ng Renee N. Ng Anna S. Tai Anna S. Tai Barbara J. Chang Stephen M. Stick Stephen M. Stick Stephen M. Stick Anthony Kicic Anthony Kicic Anthony Kicic Anthony Kicic |
author_sort |
Renee N. Ng |
title |
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis |
title_short |
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis |
title_full |
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis |
title_fullStr |
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis |
title_full_unstemmed |
Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis |
title_sort |
overcoming challenges to make bacteriophage therapy standard clinical treatment practice for cystic fibrosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2021-01-01 |
description |
Individuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial lung infection, which contributes to the growing emergence of multidrug resistant (MDR) pathogens isolated. Pathogens such as Pseudomonas aeruginosa that are commonly isolated from individuals with CF are armed with an arsenal of protective and virulence mechanisms, complicating eradication and treatment strategies. While translation of phage therapy into standard care for CF has been explored, challenges such as the lack of an appropriate animal model demonstrating safety in vivo exist. In this review, we have discussed and provided some insights in the use of primary airway epithelial cells to represent the mucoenvironment of the CF lungs to demonstrate safety and efficacy of phage therapy. The combination of phage therapy and antimicrobials is gaining attention and has the potential to delay the onset of MDR infections. It is evident that efforts to translate phage therapy into standard clinical practice have gained traction in the past 5 years. Ultimately, collaboration, transparency in data publications and standardized policies are needed for clinical translation. |
topic |
bacteriophage cystic fibrosis lung disease alternative therapy animal models antimicrobials |
url |
https://www.frontiersin.org/articles/10.3389/fmicb.2020.593988/full |
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