Perbandingan Pengaruh Premedikasi per Rektal antara Klonidin 5 μg/ kgBB dan Ketamin 10 mg/kgBB pada Anak Usia 2–5 Tahun pada Skala Pemisahan Prabedah dan Skala Kemudahan Induksi

• Main Authors: Mira Rellytania Sabirin, Ezra Oktaliansah, Ike Sri Redjeki
• Format: Article
• Language: Indonesian
• Published: Universitas Padjadjaran 2014-04-01
• Series: Jurnal Anestesi Perioperatif
• Online Access: http://journal.fk.unpad.ac.id/index.php/jap/article/view/230
• ISSN: 2337-7909; 2338-8463

Premedication in children is used to reduce pre operative anxiety and to facilitate induction. This study was designed to investigate the efficacy of rectal clonidine 5 µg/kgBW in comparison with rectal ketamine 10 mg/kgBW as a premedication in children. The study was conducted at Dr. Hasan Sadikin Hospital Bandung during the period November 2011–February 2012 with a double-blind randomized clinical controlled trials on 32 paediatric patients aged 2–5 years undergoing elective surgery and received either clonidine 5 µg/kgBW or ketamine 10 mg/kgBW rectally 45 min before induction of anesthesia. The quality of separation scale from the parent and the acceptance of mask for induction scale application during inhalation isoflurane were analyzed using Mann Whitney Test with 95% confidence interval, p value <0.05 is considered as statistically significant. Clonidine 5 µg/kgBW provide effective and good qualities of separation and acceptance of mask for induction compared to ketamine 10 mg/kgBW. These data indicate that rectal clonidine 5 µg/kgBW is effective and safe as an alternative drug for premedication in paediatric patients.