The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a hospital-acquired pathogen with high prevalence across the globe. It raises a serious health concern due to its resistance to antibiotic agents, in particular, β-lactam, carbapenem, and penem. This pathogen causes various medical con...
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doaj-25ba6b7fb2a24be0aa286268eab678252020-11-25T03:41:12ZengMcGill UniversityMcGill Journal of Medicine1715-81252020-08-01181The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureusMahsa Abbasi0Samaneh Dolatabadi1Ghazaleh Ghorbannezhad2Fatemeh Sharifi3Hamid Reza Rahimi4Student Research committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Microbiology, faculty of sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.Student Research committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a hospital-acquired pathogen with high prevalence across the globe. It raises a serious health concern due to its resistance to antibiotic agents, in particular, β-lactam, carbapenem, and penem. This pathogen causes various medical conditions, namely endocarditis, osteomyelitis, pneumonia, toxic shock syndrome (TSS), and food poisoning. Strains of lactic acid bacteria (LAB) such as Lactobacillus sp. and Bifidobacterium sp. inhibit pathogenic bacteria through competition for nutrients and adhesion sites, production of antimicrobial substances, and enhancement of immune system. The present hypothesis describes that these probiotics prevent the growth of MRSA by producing inhibitory agents like bacteriocin, lactic acid, acetic acid, propionic acid, hydrogen peroxide, and the intestinal pH reduction. Given an increasing resistance to antibiotics and its adverse effects, the use of other alternatives seems necessary. These beneficial bacteria and their metabolites which are available in the market as tablets, capsules, and powders can widely establish control over the growth of MRSA. https://mjm.mcgill.ca/article/view/156Methicillin-resistant Staphylococcus aureus (MRSA)probioticsmecA gene |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahsa Abbasi Samaneh Dolatabadi Ghazaleh Ghorbannezhad Fatemeh Sharifi Hamid Reza Rahimi |
spellingShingle |
Mahsa Abbasi Samaneh Dolatabadi Ghazaleh Ghorbannezhad Fatemeh Sharifi Hamid Reza Rahimi The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus McGill Journal of Medicine Methicillin-resistant Staphylococcus aureus (MRSA) probiotics mecA gene |
author_facet |
Mahsa Abbasi Samaneh Dolatabadi Ghazaleh Ghorbannezhad Fatemeh Sharifi Hamid Reza Rahimi |
author_sort |
Mahsa Abbasi |
title |
The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
title_short |
The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
title_full |
The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
title_fullStr |
The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
title_full_unstemmed |
The role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
title_sort |
role of probiotics in inhibition mechanism of methicillin-resistant staphylococcus aureus |
publisher |
McGill University |
series |
McGill Journal of Medicine |
issn |
1715-8125 |
publishDate |
2020-08-01 |
description |
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) is a hospital-acquired pathogen with high prevalence across the globe. It raises a serious health concern due to its resistance to antibiotic agents, in particular, β-lactam, carbapenem, and penem. This pathogen causes various medical conditions, namely endocarditis, osteomyelitis, pneumonia, toxic shock syndrome (TSS), and food poisoning. Strains of lactic acid bacteria (LAB) such as Lactobacillus sp. and Bifidobacterium sp. inhibit pathogenic bacteria through competition for nutrients and adhesion sites, production of antimicrobial substances, and enhancement of immune system. The present hypothesis describes that these probiotics prevent the growth of MRSA by producing inhibitory agents like bacteriocin, lactic acid, acetic acid, propionic acid, hydrogen peroxide, and the intestinal pH reduction. Given an increasing resistance to antibiotics and its adverse effects, the use of other alternatives seems necessary. These beneficial bacteria and their metabolites which are available in the market as tablets, capsules, and powders can widely establish control over the growth of MRSA.
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topic |
Methicillin-resistant Staphylococcus aureus (MRSA) probiotics mecA gene |
url |
https://mjm.mcgill.ca/article/view/156 |
work_keys_str_mv |
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