Anosognosia for hemiplegia as a tripartite disconnection syndrome

Anosognosia for hemiplegia as a tripartite disconnection syndrome

The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we w...

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Main Authors: Valentina Pacella, Chris Foulon, Paul M Jenkinson, Michele Scandola, Sara Bertagnoli, Renato Avesani, Aikaterini Fotopoulou, Valentina Moro, Michel Thiebaut de Schotten
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
brain
white matter
stroke
awareness
motor
disconnection
Online Access:https://elifesciences.org/articles/46075
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spelling doaj-25bacd3cd6c84341ae7c5af21a7fd2d82021-05-05T17:49:11ZengeLife Sciences Publications LtdeLife2050-084X2019-08-01810.7554/eLife.46075Anosognosia for hemiplegia as a tripartite disconnection syndromeValentina Pacella0Chris Foulon1https://orcid.org/0000-0002-7822-2653Paul M Jenkinson2Michele Scandola3Sara Bertagnoli4Renato Avesani5Aikaterini Fotopoulou6Valentina Moro7Michel Thiebaut de Schotten8https://orcid.org/0000-0002-0329-1814Social and Cognitive Neuroscience Laboratory, Department of Psychology, Sapienza University of Rome, Rome, Italy; NPSY.Lab-VR, Department of Human Sciences, University of Verona, Verona, ItalyBrain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Frontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France; Computational Neuroimaging Laboratory, Department of Diagnostic Medicine, The University of Texas at Austin Dell Medical School, Austin, United StatesSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, United KingdomNPSY.Lab-VR, Department of Human Sciences, University of Verona, Verona, ItalyNPSY.Lab-VR, Department of Human Sciences, University of Verona, Verona, ItalyDepartment of Rehabilitation, IRCSS Sacro Cuore-Don Calabria Hospital, Verona, ItalyClinical, Educational and Health Psychology, Division of Psychology and Language Sciences, University College London, London, United KingdomNPSY.Lab-VR, Department of Human Sciences, University of Verona, Verona, ItalyBrain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Frontlab, Institut du Cerveau et de la Moelle épinière (ICM), UPMC UMRS 1127, Inserm U 1127, CNRS UMR 7225, Paris, France; Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, FranceThe syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.https://elifesciences.org/articles/46075brainwhite matterstrokeawarenessmotordisconnection
collection DOAJ
language English
format Article
sources DOAJ
author Valentina Pacella
Chris Foulon
Paul M Jenkinson
Michele Scandola
Sara Bertagnoli
Renato Avesani
Aikaterini Fotopoulou
Valentina Moro
Michel Thiebaut de Schotten
spellingShingle Valentina Pacella
Chris Foulon
Paul M Jenkinson
Michele Scandola
Sara Bertagnoli
Renato Avesani
Aikaterini Fotopoulou
Valentina Moro
Michel Thiebaut de Schotten
Anosognosia for hemiplegia as a tripartite disconnection syndrome
eLife
brain
white matter
stroke
awareness
motor
disconnection
author_facet Valentina Pacella
Chris Foulon
Paul M Jenkinson
Michele Scandola
Sara Bertagnoli
Renato Avesani
Aikaterini Fotopoulou
Valentina Moro
Michel Thiebaut de Schotten
author_sort Valentina Pacella
title Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_short Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_full Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_fullStr Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_full_unstemmed Anosognosia for hemiplegia as a tripartite disconnection syndrome
title_sort anosognosia for hemiplegia as a tripartite disconnection syndrome
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2019-08-01
description The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.
topic brain
white matter
stroke
awareness
motor
disconnection
url https://elifesciences.org/articles/46075
work_keys_str_mv AT valentinapacella anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
AT chrisfoulon anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
AT paulmjenkinson anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
AT michelescandola anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
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AT renatoavesani anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
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AT michelthiebautdeschotten anosognosiaforhemiplegiaasatripartitedisconnectionsyndrome
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