Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts
Graphite oxide (GO) and reduced graphene oxide (rGO) nanosheets were synthesized with a low-cost manufacturing method. The morphology and structures of the synthesized samples were studied using X-ray diffraction (XRD), atomic force microscopy (AFM), Fourier-transform infrared (FTIR) and Raman spect...
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doaj-25c6523edf4043f9bf85936c8cf1b6812021-04-02T01:58:18ZengElsevierJournal of Pharmaceutical Analysis2095-17792015-12-015639639910.1016/j.jpha.2015.04.004Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extractsJaber NasiriElaheh MotamediMohammad Reza NaghaviGraphite oxide (GO) and reduced graphene oxide (rGO) nanosheets were synthesized with a low-cost manufacturing method. The morphology and structures of the synthesized samples were studied using X-ray diffraction (XRD), atomic force microscopy (AFM), Fourier-transform infrared (FTIR) and Raman spectroscopy. The efficiencies of GO and rGO as novel candidate adsorbents in the pre-purification of paclitaxel were compared and contrasted with those of commercial graphite (Gt), graphene (G) and multi-wall carbon nanotube (MWCNT). According to UV–vis and HPLC analyses, rGO was evaluated as the best absorbent for the removal of impurities in pre-purification of paclitaxel from plant cell cultures. In contrast, the GO had the poorest proficiency for paclitaxel pre-purification in comparison with the other carbonaceous adsorbents. This is attributed to the existence of many localized defects in the π-structure of GO that is related to weakness of π–π stacking interactions between crude extract impurities and GO.http://www.sciencedirect.com/science/article/pii/S2095177915000404PaclitaxelReduced graphene oxideGraphite oxidePurificationCarbon nanotube |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jaber Nasiri Elaheh Motamedi Mohammad Reza Naghavi |
spellingShingle |
Jaber Nasiri Elaheh Motamedi Mohammad Reza Naghavi Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts Journal of Pharmaceutical Analysis Paclitaxel Reduced graphene oxide Graphite oxide Purification Carbon nanotube |
author_facet |
Jaber Nasiri Elaheh Motamedi Mohammad Reza Naghavi |
author_sort |
Jaber Nasiri |
title |
Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts |
title_short |
Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts |
title_full |
Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts |
title_fullStr |
Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts |
title_full_unstemmed |
Comparative study of adsorptive role of carbonaceous materials in removal of UV-active impurities of paclitaxel extracts |
title_sort |
comparative study of adsorptive role of carbonaceous materials in removal of uv-active impurities of paclitaxel extracts |
publisher |
Elsevier |
series |
Journal of Pharmaceutical Analysis |
issn |
2095-1779 |
publishDate |
2015-12-01 |
description |
Graphite oxide (GO) and reduced graphene oxide (rGO) nanosheets were synthesized with a low-cost manufacturing method. The morphology and structures of the synthesized samples were studied using X-ray diffraction (XRD), atomic force microscopy (AFM), Fourier-transform infrared (FTIR) and Raman spectroscopy. The efficiencies of GO and rGO as novel candidate adsorbents in the pre-purification of paclitaxel were compared and contrasted with those of commercial graphite (Gt), graphene (G) and multi-wall carbon nanotube (MWCNT). According to UV–vis and HPLC analyses, rGO was evaluated as the best absorbent for the removal of impurities in pre-purification of paclitaxel from plant cell cultures. In contrast, the GO had the poorest proficiency for paclitaxel pre-purification in comparison with the other carbonaceous adsorbents. This is attributed to the existence of many localized defects in the π-structure of GO that is related to weakness of π–π stacking interactions between crude extract impurities and GO. |
topic |
Paclitaxel Reduced graphene oxide Graphite oxide Purification Carbon nanotube |
url |
http://www.sciencedirect.com/science/article/pii/S2095177915000404 |
work_keys_str_mv |
AT jabernasiri comparativestudyofadsorptiveroleofcarbonaceousmaterialsinremovalofuvactiveimpuritiesofpaclitaxelextracts AT elahehmotamedi comparativestudyofadsorptiveroleofcarbonaceousmaterialsinremovalofuvactiveimpuritiesofpaclitaxelextracts AT mohammadrezanaghavi comparativestudyofadsorptiveroleofcarbonaceousmaterialsinremovalofuvactiveimpuritiesofpaclitaxelextracts |
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1724174677416345600 |