New Insight into Metal Ion-Driven Catalysis of Nucleic Acids by Influenza PA-Nter.

PA subunit of influenza RNA-dependent RNA polymerase deserves constantly increasing attention due to its essential role in influenza life cycle. N-terminal domain of PA (PA-Nter) harbors endonuclease activity, which is indispensable in viral transcription and replication. Interestingly, existing lit...

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Bibliographic Details
Main Authors: Daria Kotlarek, Remigiusz Worch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4907508?pdf=render