Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models
Multiple sclerosis (MS) is a complex central nervous system inflammatory disease leading to demyelination and associated functional deficits. Though endogenous remyelination exists, it is only partial and, with time, patients can enter a progressive phase of the disease, with neurodegeneration as a...
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doaj-25c8ce56cc194c8b80037a9a48f4a8ea2021-03-12T00:02:43ZengMDPI AGLife2075-17292021-03-011123123110.3390/life11030231Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical ModelsVasiliki Pantazou0Thomas Roux1Vanessa Oliveira Moreira2Catherine Lubetzki3Anne Desmazières4Paris Brain Institute (ICM), Sorbonne Université, CNRS, Inserm, GH Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, FranceParis Brain Institute (ICM), Sorbonne Université, CNRS, Inserm, GH Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, FranceParis Brain Institute (ICM), Sorbonne Université, CNRS, Inserm, GH Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, FranceParis Brain Institute (ICM), Sorbonne Université, CNRS, Inserm, GH Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, FranceParis Brain Institute (ICM), Sorbonne Université, CNRS, Inserm, GH Pitié-Salpêtrière, 47 boulevard de l’Hôpital, 75013 Paris, FranceMultiple sclerosis (MS) is a complex central nervous system inflammatory disease leading to demyelination and associated functional deficits. Though endogenous remyelination exists, it is only partial and, with time, patients can enter a progressive phase of the disease, with neurodegeneration as a hallmark. Though major therapeutic advances have been made, with immunotherapies reducing relapse rate during the inflammatory phase of MS, there is presently no therapy available which significantly impacts disease progression. Remyelination has been shown to favor neuroprotection, and it is thus of major importance to better understand remyelination mechanisms in order to promote them and hence preserve neurons. A crucial point is how this process is regulated through the neuronal crosstalk with the oligodendroglial lineage. In this review, we present the current knowledge on neuron interaction with the oligodendroglial lineage, in physiological context as well as in MS and its experimental models. We further discuss the therapeutic possibilities resulting from this research field, which might allow to support remyelination and neuroprotection and thus limit MS progression.https://www.mdpi.com/2075-1729/11/3/231oligodendrocytesgliamyelinneuronmyelinationmultiple sclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vasiliki Pantazou Thomas Roux Vanessa Oliveira Moreira Catherine Lubetzki Anne Desmazières |
spellingShingle |
Vasiliki Pantazou Thomas Roux Vanessa Oliveira Moreira Catherine Lubetzki Anne Desmazières Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models Life oligodendrocytes glia myelin neuron myelination multiple sclerosis |
author_facet |
Vasiliki Pantazou Thomas Roux Vanessa Oliveira Moreira Catherine Lubetzki Anne Desmazières |
author_sort |
Vasiliki Pantazou |
title |
Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models |
title_short |
Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models |
title_full |
Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models |
title_fullStr |
Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models |
title_full_unstemmed |
Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models |
title_sort |
interaction between neurons and the oligodendroglial lineage in multiple sclerosis and its preclinical models |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2021-03-01 |
description |
Multiple sclerosis (MS) is a complex central nervous system inflammatory disease leading to demyelination and associated functional deficits. Though endogenous remyelination exists, it is only partial and, with time, patients can enter a progressive phase of the disease, with neurodegeneration as a hallmark. Though major therapeutic advances have been made, with immunotherapies reducing relapse rate during the inflammatory phase of MS, there is presently no therapy available which significantly impacts disease progression. Remyelination has been shown to favor neuroprotection, and it is thus of major importance to better understand remyelination mechanisms in order to promote them and hence preserve neurons. A crucial point is how this process is regulated through the neuronal crosstalk with the oligodendroglial lineage. In this review, we present the current knowledge on neuron interaction with the oligodendroglial lineage, in physiological context as well as in MS and its experimental models. We further discuss the therapeutic possibilities resulting from this research field, which might allow to support remyelination and neuroprotection and thus limit MS progression. |
topic |
oligodendrocytes glia myelin neuron myelination multiple sclerosis |
url |
https://www.mdpi.com/2075-1729/11/3/231 |
work_keys_str_mv |
AT vasilikipantazou interactionbetweenneuronsandtheoligodendrogliallineageinmultiplesclerosisanditspreclinicalmodels AT thomasroux interactionbetweenneuronsandtheoligodendrogliallineageinmultiplesclerosisanditspreclinicalmodels AT vanessaoliveiramoreira interactionbetweenneuronsandtheoligodendrogliallineageinmultiplesclerosisanditspreclinicalmodels AT catherinelubetzki interactionbetweenneuronsandtheoligodendrogliallineageinmultiplesclerosisanditspreclinicalmodels AT annedesmazieres interactionbetweenneuronsandtheoligodendrogliallineageinmultiplesclerosisanditspreclinicalmodels |
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