Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal p...
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doaj-25d1ae30496342289d91bb44be7019f22021-05-20T06:55:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.671044671044Exploiting Radiation Therapy to Restore Immune Reactivity of GlioblastomaMara De Martino0Oscar Padilla1Camille Daviaud2Cheng-Chia Wu3Cheng-Chia Wu4Robyn D. Gartrell5Claire Vanpouille-Box6Claire Vanpouille-Box7Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, United StatesDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, United StatesDepartment of Radiation Oncology, Columbia University Irving Medical Center, New York, NY, United StatesHerbert Irving Comprehensive Cancer Center, New York, NY, United StatesDepartment of Pediatrics, Pediatric Hematology/Oncology/SCT, Columbia University Irving Medical Center, New York, NY, United StatesDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, United StatesSandra and Edward Meyer Cancer Center, New York, NY, United StatesGlioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and determine the best combinations of therapies, including radiation. We highlight important features of the tumor immune microenvironment in GBM and potential for combining radiation and immunotherapy to improve prognosis in this devastating disease.https://www.frontiersin.org/articles/10.3389/fonc.2021.671044/fullglioblastomaradiotherapyimmunotherapyantigenicityadjuvanticityimmunosuppression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mara De Martino Oscar Padilla Camille Daviaud Cheng-Chia Wu Cheng-Chia Wu Robyn D. Gartrell Claire Vanpouille-Box Claire Vanpouille-Box |
spellingShingle |
Mara De Martino Oscar Padilla Camille Daviaud Cheng-Chia Wu Cheng-Chia Wu Robyn D. Gartrell Claire Vanpouille-Box Claire Vanpouille-Box Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma Frontiers in Oncology glioblastoma radiotherapy immunotherapy antigenicity adjuvanticity immunosuppression |
author_facet |
Mara De Martino Oscar Padilla Camille Daviaud Cheng-Chia Wu Cheng-Chia Wu Robyn D. Gartrell Claire Vanpouille-Box Claire Vanpouille-Box |
author_sort |
Mara De Martino |
title |
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma |
title_short |
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma |
title_full |
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma |
title_fullStr |
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma |
title_full_unstemmed |
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma |
title_sort |
exploiting radiation therapy to restore immune reactivity of glioblastoma |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-05-01 |
description |
Glioblastoma (GBM) is among the most aggressive of brain tumors and confers a dismal prognosis despite advances in surgical technique, radiation delivery methods, chemotherapy, and tumor-treating fields. While immunotherapy (IT) has improved the care of several adult cancers with previously dismal prognoses, monotherapy with IT in GBM has shown minimal response in first recurrence. Recent discoveries in lymphatics and evaluation of blood brain barrier offer insight to improve the use of ITs and determine the best combinations of therapies, including radiation. We highlight important features of the tumor immune microenvironment in GBM and potential for combining radiation and immunotherapy to improve prognosis in this devastating disease. |
topic |
glioblastoma radiotherapy immunotherapy antigenicity adjuvanticity immunosuppression |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.671044/full |
work_keys_str_mv |
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