Sezary syndrome manifesting as posttransplant lymphoproliferative disorder

Sezary syndrome manifesting as posttransplant lymphoproliferative disorder

Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been desc...

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Main Authors: Thanh-Phuong Afiat, Xiaohui Zhang, Hailing Zhang, Ernesto Ayala, Ling Zhang, Lubomir Sokol
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048918300232
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spelling doaj-25d31fd200d34d70914604dd60e9c9172020-11-24T21:36:55ZengElsevierLeukemia Research Reports2213-04892018-01-0197275Sezary syndrome manifesting as posttransplant lymphoproliferative disorderThanh-Phuong Afiat0Xiaohui Zhang1Hailing Zhang2Ernesto Ayala3Ling Zhang4Lubomir Sokol5Department of Internal Medicine, College of Medicine, University of South Florida, 12902 USF Magnolia Drive, Tampa, FL 33612, USADepartment of Hematopathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL, USADepartment of Hematopathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL, USADepartment of Blood and Marrow Transplant, Moffitt Cancer Center, Tampa, FL, USADepartment of Hematopathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL, USADepartment of Malignant Hematology, Moffitt Cancer Center, Tampa, FL, USA; Corresponding author.Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been described so far. We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin.http://www.sciencedirect.com/science/article/pii/S2213048918300232
collection DOAJ
language English
format Article
sources DOAJ
author Thanh-Phuong Afiat
Xiaohui Zhang
Hailing Zhang
Ernesto Ayala
Ling Zhang
Lubomir Sokol
spellingShingle Thanh-Phuong Afiat
Xiaohui Zhang
Hailing Zhang
Ernesto Ayala
Ling Zhang
Lubomir Sokol
Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
Leukemia Research Reports
author_facet Thanh-Phuong Afiat
Xiaohui Zhang
Hailing Zhang
Ernesto Ayala
Ling Zhang
Lubomir Sokol
author_sort Thanh-Phuong Afiat
title Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
title_short Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
title_full Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
title_fullStr Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
title_full_unstemmed Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
title_sort sezary syndrome manifesting as posttransplant lymphoproliferative disorder
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2018-01-01
description Posttransplant lymphoproliferative disorders (PTLDs) of T-cell orgin are rare biologically heterogeneous diseases of mature lymphoid cells manifesting in immunosuppressed patients. Only a few cases of mycosis fungoides diagnosed post allogeneic hematopoietic cell transplant (alloHSCT) have been described so far. We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin.
url http://www.sciencedirect.com/science/article/pii/S2213048918300232
work_keys_str_mv AT thanhphuongafiat sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
AT xiaohuizhang sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
AT hailingzhang sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
AT ernestoayala sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
AT lingzhang sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
AT lubomirsokol sezarysyndromemanifestingasposttransplantlymphoproliferativedisorder
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