Pathological ATX3 Expression Induces Cell Perturbations in <i>E. coli</i> as Revealed by Biochemical and Biophysical Investigations

Pathological ATX3 Expression Induces Cell Perturbations in <i>E. coli</i> as Revealed by Biochemical and Biophysical Investigations

Amyloid aggregation of human ataxin-3 (ATX3) is responsible for spinocerebellar ataxia type 3, which belongs to the class of polyglutamine neurodegenerative disorders. It is widely accepted that the formation of toxic oligomeric species is primarily involved in the onset of the disease. For this rea...

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Bibliographic Details
Main Authors: Diletta Ami, Barbara Sciandrone, Paolo Mereghetti, Jacopo Falvo, Tiziano Catelani, Cristina Visentin, Paolo Tortora, Salvador Ventura, Antonino Natalello, Maria Elena Regonesi
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
ataxin-3 expression
amyloids
<i>Escherichia coli</i>
FTIR microspectroscopy
multivariate analysis
oligomer toxicity
Online Access:https://www.mdpi.com/1422-0067/22/2/943

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