Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer
Abstract Background This study aimed to assess the correlation of katanin P60 expression with clinical characteristics and survival profiles of surgical non-small cell lung cancer (NSCLC) patients. Methods Two hundred and sixty-five primary NSCLC patients treated by surgical resection were retrospec...
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doaj-25fe9e337f88450789a72fdfbe821d422020-11-25T02:41:22ZengBMCWorld Journal of Surgical Oncology1477-78192020-07-011811810.1186/s12957-020-01939-zKatanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancerLei Wang0Jicheng Tantai1Xiaoli Zhu2Department of Interventional Radiology, The First Affiliated Hospital of Soochow UniversityDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong UniversityDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow UniversityAbstract Background This study aimed to assess the correlation of katanin P60 expression with clinical characteristics and survival profiles of surgical non-small cell lung cancer (NSCLC) patients. Methods Two hundred and sixty-five primary NSCLC patients treated by surgical resection were retrospectively viewed. The expression of katanin P60 in the tumor specimen was detected by the immunohistochemical (IHC) staining assay. Preoperative clinical data were collected from patients’ medical records, and survival data were extracted from follow-up records. Results There were 127 (47.9%) and 138 (52.1%) patients with katanin P60-low expression and -high expression, respectively; in addition, patients presenting katanin P60-high+, -high++, and -high+++ expression were 62 (23.4%), 63 (23.8%), and 13 (4.9%), respectively. Katanin P60 expression was correlated with lymph node (LYN) metastasis and advanced TNM stage but not pathological grade, tumor size, carcinoembryonic antigen (CEA) level or other non-tumor features in NSCLC patients. Regarding survival profiles, disease-free survival (DFS) and overall survival (OS) were both the lowest in katanin P60-high+++ expression patients, followed with katanin P60-high++ patients, katanin P60-high+ patients, and the highest in katanin P60-low expression patients. Further analysis illustrated that katanin P60-high expression was an independent predictive factor for unfavorable DFS and OS in NSCLC patients. Conclusions Katanin P60 presents potential as a biomarker for lymph node metastasis and prognosis in NSCLC patients.http://link.springer.com/article/10.1186/s12957-020-01939-zKatanin P60Lymph node metastasisSurvivalTumor progressionNon-small cell lung cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Wang Jicheng Tantai Xiaoli Zhu |
spellingShingle |
Lei Wang Jicheng Tantai Xiaoli Zhu Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer World Journal of Surgical Oncology Katanin P60 Lymph node metastasis Survival Tumor progression Non-small cell lung cancer |
author_facet |
Lei Wang Jicheng Tantai Xiaoli Zhu |
author_sort |
Lei Wang |
title |
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
title_short |
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
title_full |
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
title_fullStr |
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
title_full_unstemmed |
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
title_sort |
katanin p60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2020-07-01 |
description |
Abstract Background This study aimed to assess the correlation of katanin P60 expression with clinical characteristics and survival profiles of surgical non-small cell lung cancer (NSCLC) patients. Methods Two hundred and sixty-five primary NSCLC patients treated by surgical resection were retrospectively viewed. The expression of katanin P60 in the tumor specimen was detected by the immunohistochemical (IHC) staining assay. Preoperative clinical data were collected from patients’ medical records, and survival data were extracted from follow-up records. Results There were 127 (47.9%) and 138 (52.1%) patients with katanin P60-low expression and -high expression, respectively; in addition, patients presenting katanin P60-high+, -high++, and -high+++ expression were 62 (23.4%), 63 (23.8%), and 13 (4.9%), respectively. Katanin P60 expression was correlated with lymph node (LYN) metastasis and advanced TNM stage but not pathological grade, tumor size, carcinoembryonic antigen (CEA) level or other non-tumor features in NSCLC patients. Regarding survival profiles, disease-free survival (DFS) and overall survival (OS) were both the lowest in katanin P60-high+++ expression patients, followed with katanin P60-high++ patients, katanin P60-high+ patients, and the highest in katanin P60-low expression patients. Further analysis illustrated that katanin P60-high expression was an independent predictive factor for unfavorable DFS and OS in NSCLC patients. Conclusions Katanin P60 presents potential as a biomarker for lymph node metastasis and prognosis in NSCLC patients. |
topic |
Katanin P60 Lymph node metastasis Survival Tumor progression Non-small cell lung cancer |
url |
http://link.springer.com/article/10.1186/s12957-020-01939-z |
work_keys_str_mv |
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