Optimization of experimental human leukemia models (review)

• Main Authors: D. D. Pankov, A. G. Rumyantsev
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Series: Onkogematologiâ
• Subjects: immunotherapy; antigen-specific cell therapy; animal models; immunodeficient mice; NOD/SCID; NSG; WT1
• Online Access: http://oncohematology.abvpress.ru/index.php/ongm/article/view/76

<p>Actual problem of assessing immunotherapy prospects including antigenpecific cell therapy using animal models was covered in this review.<br />Describe the various groups of currently existing animal models and methods of their creating – from different immunodeficient mice to several<br />variants of tumor cells engraftment in them. The review addresses the possibility of tumor stem cells studying using mouse models for the leukemia treatment with adoptive cell therapy including WT1. Also issues of human leukemia cells migration and proliferation in a mice with<br />different immunodeficiency degree are discussed. To assess the potential immunotherapy efficacy comparison of immunodeficient mouse model with clinical situation in oncology patients after chemotherapy is proposed.</p>