Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1/Srebp-1/Pparɑ Pathway in Juvenile Black Seabream (Acanthopagrus schlegelii)

Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1/Srebp-1/Pparɑ Pathway in Juvenile Black Seabream (Acanthopagrus schlegelii)

The present study aimed to elucidate the mechanism of dietary betaine, as a lipid-lowering substance, on the regulation of lipid metabolism and inflammation in juvenile black seabream (Acanthopagrus schlegelii) fed a high fat diet. An 8-week feeding trial was conducted in black seabream with an init...

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Bibliographic Details
Main Authors: Min Jin, Yuedong Shen, Tingting Pan, Tingting Zhu, Xuejiao Li, Fangmin Xu, Mónica B. Betancor, Lefei Jiao, Douglas R. Tocher, Qicun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
betaine
hepatic steatosis
high-fat diet
inflammation response
Sirt1/Srebp-1/Pparɑ
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.694720/full

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