Breast Cancer Cell-Derived Adenosine Enhances Generation and Suppressor Function of Human Adaptive Regulatory T Cells
Introduction: Adaptive regulatory T cells (Tr1) are induced in the periphery by environmental stimuli. CD73 expression and adenosine (ADO) production by tumor cells may influence Tr1 generation and their immunosuppressive activity. Material and Methods: Tr1 were generated in co-cultures of CD4+CD25n...
Main Authors: | Magis Mandapathil, Miroslaw J. Szczepanski, Edwin K. Jackson, Stephan Lang, Theresa L. Whiteside |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
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Series: | Journal of Personalized Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-4426/11/8/754 |
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