Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Lysophosphatidic acid (LPA) species in the extracellular environment induce downstream signaling via six different G protein-coupled receptors (LPAR1–6). These signaling cascades are essential for normal brain development and function of the nervous system. However, in response to acute or chronic c...

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Bibliographic Details
Main Authors: Ioanna Plastira, Lisha Joshi, Eva Bernhart, Jens Schoene, Edgar Specker, Marc Nazare, Wolfgang Sattler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
LPA5
microglia
chemokines
cytokines
neurotoxicity
transcription factors
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00531/full

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