Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy

Transmembrane Tumor Necrosis Factor Controls Myeloid-Derived Suppressor Cell Activity via TNF Receptor 2 and Protects from Excessive Inflammation during BCG-Induced Pleurisy

Pleural tuberculosis (TB) is a form of extra-pulmonary TB observed in patients infected with Mycobacterium tuberculosis. Accumulation of myeloid-derived suppressor cells (MDSC) has been observed in animal models of TB and in human patients but their role remains to be fully elucidated. In this study...

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Bibliographic Details
Main Authors: Leslie Chavez-Galan, Dominique Vesin, Husnu Uysal, Guillaume Blaser, Mahdia Benkhoucha, Bernhard Ryffel, Valérie F. J. Quesniaux, Irene Garcia
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
transmembrane tumor necrosis factor
TNF receptor 2
myeloid-derived suppressor cells
BCG infection
BCG-induced pleurisy
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00999/full

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