| Summary: | Abstract Background Photonic crystal fiber Mach-Zehnder modal interferometers based on no adiabatic tapered fibers are perspective for bio-chemical sensing, since they have very high refractive index sensitivity and it is possible for them to use a very small quantity of investigated samples. To obtain a desirable sensitivity to a needed analyte, it was proposed to coat a sensing surface of the refractive index sensor with ultra-thin films. Methods In this work, we reported on a no adiabatic tapered special photonic crystal fiber coated with an ultra-thin layer of a Bovine Serum Albumin (BSA) antigen or with an 8 nm palladium film to detect interaction between the BSA antigen and an anti-BSA antibody or for fast detection of hydrogen concentrations, respectively. Results and conclusion During our experiments, we received a record detection limit of 125 pg/ml of the anti-BSA antibody concentration. Fast detection of hydrogen concentrations up to 5.6 vol% was carried out. By using a proposed electrodynamics model of a hydrogen sensor, an optimal taper sensing length was determined.
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