CTR1 silencing inhibits angiogenesis by limiting copper entry into endothelial cells.
Increased levels of intracellular copper stimulate angiogenesis in human umbilical vein endothelial cells (HUVECs). Copper transporter 1 (CTR1) is a copper importer present in the cell membrane and plays a major role in copper transport. In this study, three siRNAs targeting CTR1 mRNA were designed...
Main Authors: | Gomathy Narayanan, Bharathidevi S R, Harish Vuyyuru, Bharathselvi Muthuvel, Sulochana Konerirajapuram Natrajan |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3767743?pdf=render |
Similar Items
-
Copper-dependent trafficking of the Ctr4-Ctr5 copper transporting complex.
by: Raphaël Ioannoni, et al.
Published: (2010-08-01) -
Homocysteine & its metabolite homocysteine-thiolactone & deficiency of copper in patients with age related macular degeneration - A pilot study
by: Muthuvel Bharathselvi, et al.
Published: (2016-01-01) -
Authors' Response
by: Muthuvel Bharathselvi, et al.
Published: (2017-01-01) -
The Rhizophagus irregularis Genome Encodes Two CTR Copper Transporters That Mediate Cu Import Into the Cytosol and a CTR-Like Protein Likely Involved in Copper Tolerance
by: Tamara Gómez-Gallego, et al.
Published: (2019-05-01) -
X-ray structures of the high-affinity copper transporter Ctr1
by: Feifei Ren, et al.
Published: (2019-03-01)