Chromosomal copy number heterogeneity predicts survival rates across cancers

Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.

Bibliographic Details
Main Authors:	Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23384-6

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spelling	doaj-264d1331d97845559b189b69b84d9dcb2021-05-30T11:13:00ZengNature Publishing GroupNature Communications2041-17232021-05-0112111210.1038/s41467-021-23384-6Chromosomal copy number heterogeneity predicts survival rates across cancersErik van Dijk0Tom van den Bosch1Kristiaan J. Lenos2Khalid El Makrini3Lisanne E. Nijman4Hendrik F. B. van Essen5Nico Lansu6Michiel Boekhout7Joris H. Hageman8Rebecca C. Fitzgerald9Cornelis J. A. Punt10Jurriaan B. Tuynman11Hugo J. G. Snippert12Geert J. P. L. Kops13Jan Paul Medema14Bauke Ylstra15Louis Vermeulen16Daniël M. Miedema17Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamOncode InstituteOncode InstituteOncode InstituteMRC Cancer Unit, University of CambridgeDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtDepartment of Surgery, Amsterdam UMC, Vrije Universiteit AmsterdamOncode InstituteOncode InstituteLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamLEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of AmsterdamIntratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.https://doi.org/10.1038/s41467-021-23384-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Erik van Dijk Tom van den Bosch Kristiaan J. Lenos Khalid El Makrini Lisanne E. Nijman Hendrik F. B. van Essen Nico Lansu Michiel Boekhout Joris H. Hageman Rebecca C. Fitzgerald Cornelis J. A. Punt Jurriaan B. Tuynman Hugo J. G. Snippert Geert J. P. L. Kops Jan Paul Medema Bauke Ylstra Louis Vermeulen Daniël M. Miedema
spellingShingle	Erik van Dijk Tom van den Bosch Kristiaan J. Lenos Khalid El Makrini Lisanne E. Nijman Hendrik F. B. van Essen Nico Lansu Michiel Boekhout Joris H. Hageman Rebecca C. Fitzgerald Cornelis J. A. Punt Jurriaan B. Tuynman Hugo J. G. Snippert Geert J. P. L. Kops Jan Paul Medema Bauke Ylstra Louis Vermeulen Daniël M. Miedema Chromosomal copy number heterogeneity predicts survival rates across cancers Nature Communications
author_facet	Erik van Dijk Tom van den Bosch Kristiaan J. Lenos Khalid El Makrini Lisanne E. Nijman Hendrik F. B. van Essen Nico Lansu Michiel Boekhout Joris H. Hageman Rebecca C. Fitzgerald Cornelis J. A. Punt Jurriaan B. Tuynman Hugo J. G. Snippert Geert J. P. L. Kops Jan Paul Medema Bauke Ylstra Louis Vermeulen Daniël M. Miedema
author_sort	Erik van Dijk
title	Chromosomal copy number heterogeneity predicts survival rates across cancers
title_short	Chromosomal copy number heterogeneity predicts survival rates across cancers
title_full	Chromosomal copy number heterogeneity predicts survival rates across cancers
title_fullStr	Chromosomal copy number heterogeneity predicts survival rates across cancers
title_full_unstemmed	Chromosomal copy number heterogeneity predicts survival rates across cancers
title_sort	chromosomal copy number heterogeneity predicts survival rates across cancers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.
url	https://doi.org/10.1038/s41467-021-23384-6
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Chromosomal copy number heterogeneity predicts survival rates across cancers

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