Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms
Unipolar atrial fibrillation (AF) electrograms (EGMs) require far-field ventricle cancellation to recover hidden atrial activations. Current methods cannot achieve real-time cancellation because of the temporal delay they introduce. We propose a new real-time ventricular cancellation (RVC) method ba...
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2020-07-01
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doaj-2652b92dcb434222adabd7639f41ead22020-11-25T01:28:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-07-01810.3389/fbioe.2020.00789557033Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation ElectrogramsGonzalo R. Ríos-Muñoz0Gonzalo R. Ríos-Muñoz1Gonzalo R. Ríos-Muñoz2Gonzalo R. Ríos-Muñoz3Antonio Artés-Rodríguez4Antonio Artés-Rodríguez5Francisco Fernández-Avilés6Francisco Fernández-Avilés7Francisco Fernández-Avilés8Francisco Fernández-Avilés9Francisco Fernández-Avilés10Ángel Arenal11Ángel Arenal12Ángel Arenal13Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, SpainLa Red de Terapia Celular (TerCel), Instituto de Salud Carlos III, Madrid, SpainDepartamento de Cardiología, Hospital General Universitario Gregorio Marañón, Madrid, SpainDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, SpainDepartamento de Teoría de la Señal y Comunicaciones, Universidad Carlos III de Madrid, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, SpainLa Red de Terapia Celular (TerCel), Instituto de Salud Carlos III, Madrid, SpainDepartamento de Cardiología, Hospital General Universitario Gregorio Marañón, Madrid, SpainCenter for Biomedical Research in Cardiovascular Disease Network (CIBERCV), Madrid, SpainFacultad de Medicina, Universidad Complutense de Madrid, Madrid, SpainInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, SpainLa Red de Terapia Celular (TerCel), Instituto de Salud Carlos III, Madrid, SpainCenter for Biomedical Research in Cardiovascular Disease Network (CIBERCV), Madrid, SpainUnipolar atrial fibrillation (AF) electrograms (EGMs) require far-field ventricle cancellation to recover hidden atrial activations. Current methods cannot achieve real-time cancellation because of the temporal delay they introduce. We propose a new real-time ventricular cancellation (RVC) method based on causal implementation optimized for real-time functioning. The method is similar to the classical average beat subtraction (ABS) method but it computes the ventricular contribution before the ventricular activation finishes. We compare the proposed method to the ABS on synthetic and real EGM databases for the time and frequency domains. All parameters and their optimal values are analyzed and validated. The RVC method provides a good reconstruction of the unipolar EGMs and a better local activation time detection than the classical approach with average F1scores 0.7307 and 0.7125, respectively. The spectral analysis shows that the average power after ventricular cancellation is reduced for frequency bands between 3 and 5.5 Hz, demonstrating that the proposed method removes the ventricular component present in the unipolar EGM signals compared to the ABS method. The phase mapping analysis on the RVC method presented lower error when comparing the annotated EGM cycles with the phase inversion intervals. In terms of performance ABS and RVC behave similarly, but the real-time capability of the latter justifies its preference over the offline implementations. In the clinical environment other online investigations, e.g., rotational activity assessment, dominant frequency or local activation time mapping, might benefit from the real-time potential of the proposed cancellation method.https://www.frontiersin.org/article/10.3389/fbioe.2020.00789/fullatrial fibrillationunipolar electrogramsreal-timebiomedical signal processingmulti-electrode catheter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Antonio Artés-Rodríguez Antonio Artés-Rodríguez Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Ángel Arenal Ángel Arenal Ángel Arenal |
spellingShingle |
Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Antonio Artés-Rodríguez Antonio Artés-Rodríguez Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Ángel Arenal Ángel Arenal Ángel Arenal Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms Frontiers in Bioengineering and Biotechnology atrial fibrillation unipolar electrograms real-time biomedical signal processing multi-electrode catheter |
author_facet |
Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Gonzalo R. Ríos-Muñoz Antonio Artés-Rodríguez Antonio Artés-Rodríguez Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Francisco Fernández-Avilés Ángel Arenal Ángel Arenal Ángel Arenal |
author_sort |
Gonzalo R. Ríos-Muñoz |
title |
Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms |
title_short |
Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms |
title_full |
Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms |
title_fullStr |
Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms |
title_full_unstemmed |
Real-Time Ventricular Cancellation in Unipolar Atrial Fibrillation Electrograms |
title_sort |
real-time ventricular cancellation in unipolar atrial fibrillation electrograms |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2020-07-01 |
description |
Unipolar atrial fibrillation (AF) electrograms (EGMs) require far-field ventricle cancellation to recover hidden atrial activations. Current methods cannot achieve real-time cancellation because of the temporal delay they introduce. We propose a new real-time ventricular cancellation (RVC) method based on causal implementation optimized for real-time functioning. The method is similar to the classical average beat subtraction (ABS) method but it computes the ventricular contribution before the ventricular activation finishes. We compare the proposed method to the ABS on synthetic and real EGM databases for the time and frequency domains. All parameters and their optimal values are analyzed and validated. The RVC method provides a good reconstruction of the unipolar EGMs and a better local activation time detection than the classical approach with average F1scores 0.7307 and 0.7125, respectively. The spectral analysis shows that the average power after ventricular cancellation is reduced for frequency bands between 3 and 5.5 Hz, demonstrating that the proposed method removes the ventricular component present in the unipolar EGM signals compared to the ABS method. The phase mapping analysis on the RVC method presented lower error when comparing the annotated EGM cycles with the phase inversion intervals. In terms of performance ABS and RVC behave similarly, but the real-time capability of the latter justifies its preference over the offline implementations. In the clinical environment other online investigations, e.g., rotational activity assessment, dominant frequency or local activation time mapping, might benefit from the real-time potential of the proposed cancellation method. |
topic |
atrial fibrillation unipolar electrograms real-time biomedical signal processing multi-electrode catheter |
url |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00789/full |
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