Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy
PURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy. MATERIALS AND METHODS:A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy....
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Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
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doaj-2652cbb666924b88971571428b14fb502020-11-25T00:57:27ZengUrology and Nephrology Research Center, Shahid Beheshti University of Medical SciencesUrology Journal1735-13081735-546X2013-03-01101784789Long-Term Renal Function Outcomes in Bladder Cancer After Radical CystectomyTakahiro OsawaNobuo ShinoharaSatoru MaruyamaKoji ObaTakashige Abe,Shintaro MaruNorikata TakadaAtaru SazawaKatsuya NonomuraPURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy. MATERIALS AND METHODS:A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy. The median follow-up period was 34.5 months (range, 12 to 228 months). In this cohort, four types of urinary diversions were studied, including ilealneobladder (n = 24), ileocecalneobladder (n = 12), ileal conduit (n = 25), and cutaneous ureterostomy (n = 9). Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated. The variables analyzed were age, a prior history of hypertension or diabetes mellitus, pre-operative renal function, type of urinary diversion, the postoperative occurrence of acute pyelonephritis, and the presence of chemotherapy. RESULTS: The mean eGFR was 74.6 (range, 15.2 to 155.1) mL/min/1.73 m2 before surgery and 63.6 (range, 8.7 to 111.5) mL/min/1.73 m2 at the last follow-up. The 10-year renal deterioration-free interval was 63.8%. Multivariate analysis showed that a postoperative episode of acute pyelonephritis [Odds Ratio (OR), 3.21; 95% Confidence Interval (CI), 1.14 to 9.02; P = .03] and the presence of chemotherapy (OR, 3.27; 95% CI, 1.33 to 8.01; P = .01) were significant adverse factors. CONCLUSION: Twenty-four (34.2%) patients demonstrated reduced renal function during the follow-up period. Postoperative episodes of acute pyelonephritis and the presence of chemotherapy were found to be significant adverse factors. http://www.urologyjournal.org/index.php/uj/article/view/1973urinary bladder neoplasmsurinary diversionfollow-up studiestreatment outcomecystectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takahiro Osawa Nobuo Shinohara Satoru Maruyama Koji Oba Takashige Abe, Shintaro Maru Norikata Takada Ataru Sazawa Katsuya Nonomura |
spellingShingle |
Takahiro Osawa Nobuo Shinohara Satoru Maruyama Koji Oba Takashige Abe, Shintaro Maru Norikata Takada Ataru Sazawa Katsuya Nonomura Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy Urology Journal urinary bladder neoplasms urinary diversion follow-up studies treatment outcome cystectomy |
author_facet |
Takahiro Osawa Nobuo Shinohara Satoru Maruyama Koji Oba Takashige Abe, Shintaro Maru Norikata Takada Ataru Sazawa Katsuya Nonomura |
author_sort |
Takahiro Osawa |
title |
Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy |
title_short |
Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy |
title_full |
Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy |
title_fullStr |
Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy |
title_full_unstemmed |
Long-Term Renal Function Outcomes in Bladder Cancer After Radical Cystectomy |
title_sort |
long-term renal function outcomes in bladder cancer after radical cystectomy |
publisher |
Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences |
series |
Urology Journal |
issn |
1735-1308 1735-546X |
publishDate |
2013-03-01 |
description |
PURPOSE: To evaluate postoperative renal function and risk factors for the loss of renal function in patients who had undergone radical cystectomy. MATERIALS AND METHODS:A retrospective single institutional study evaluated 70 patients, including 54 men and 16 women who underwent radical cystectomy. The median follow-up period was 34.5 months (range, 12 to 228 months). In this cohort, four types of urinary diversions were studied, including ilealneobladder (n = 24), ileocecalneobladder (n = 12), ileal conduit (n = 25), and cutaneous ureterostomy (n = 9). Postoperative changes in renal function were reviewed, and the estimated serum creatinine-based glomerular filtration rate (eGFR) was calculated. The variables analyzed were age, a prior history of hypertension or diabetes mellitus, pre-operative renal function, type of urinary diversion, the postoperative occurrence of acute pyelonephritis, and the presence of chemotherapy. RESULTS: The mean eGFR was 74.6 (range, 15.2 to 155.1) mL/min/1.73 m2 before surgery and 63.6 (range, 8.7 to 111.5) mL/min/1.73 m2 at the last follow-up. The 10-year renal deterioration-free interval was 63.8%. Multivariate analysis showed that a postoperative episode of acute pyelonephritis [Odds Ratio (OR), 3.21; 95% Confidence Interval (CI), 1.14 to 9.02; P = .03] and the presence of chemotherapy (OR, 3.27; 95% CI, 1.33 to 8.01; P = .01) were significant adverse factors. CONCLUSION: Twenty-four (34.2%) patients demonstrated reduced renal function during the follow-up period. Postoperative episodes of acute pyelonephritis and the presence of chemotherapy were found to be significant adverse factors. |
topic |
urinary bladder neoplasms urinary diversion follow-up studies treatment outcome cystectomy |
url |
http://www.urologyjournal.org/index.php/uj/article/view/1973 |
work_keys_str_mv |
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