Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases
The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem, affecting a huge population around the globe. However, CVDs (cardiovascular diseases) are the most common cause of mortality in NAFLD patients. Atherogenic dyslipidemia, characterized by plasma hypertriglyce...
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doaj-26615bbca56d43d084e694fd8cffa33b2021-07-15T15:37:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226949694910.3390/ijms22136949Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart DiseasesSiarhei A. Dabravolski0Evgeny E. Bezsonov1Mirza S. Baig2Tatyana V. Popkova3Alexander N. Orekhov4Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine (UO VGAVM), 7/11 Dovatora Street, 210026 Vitebsk, BelarusLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, RussiaDepartment of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol 453552, IndiaV.A. Nasonova Institute of Rheumatology, 34A Kashirskoye Shosse, 115522 Moscow, RussiaLaboratory of Cellular and Molecular Pathology of Cardiovascular System, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, RussiaThe prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem, affecting a huge population around the globe. However, CVDs (cardiovascular diseases) are the most common cause of mortality in NAFLD patients. Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense LDL (low-density lipoprotein) particles, and decreased HDL-C (high-density lipoprotein cholesterol) levels, is often observed in NAFLD patients. In this review, we summarize recent genetic evidence, proving the diverse nature of metabolic pathways involved in NAFLD pathogenesis. Analysis of available genetic data suggests that the altered operation of fatty-acid β-oxidation in liver mitochondria is the key process, connecting NAFLD-mediated dyslipidemia and elevated CVD risk. In addition, we discuss several NAFLD-associated genes with documented anti-atherosclerotic or cardioprotective effects, and current pharmaceutical strategies focused on both NAFLD treatment and reduction of CVD risk.https://www.mdpi.com/1422-0067/22/13/6949NAFLDcardiovascular diseasedyslipidemiaatherosclerosisfatty-acid β-oxidationlipid metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siarhei A. Dabravolski Evgeny E. Bezsonov Mirza S. Baig Tatyana V. Popkova Alexander N. Orekhov |
spellingShingle |
Siarhei A. Dabravolski Evgeny E. Bezsonov Mirza S. Baig Tatyana V. Popkova Alexander N. Orekhov Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases International Journal of Molecular Sciences NAFLD cardiovascular disease dyslipidemia atherosclerosis fatty-acid β-oxidation lipid metabolism |
author_facet |
Siarhei A. Dabravolski Evgeny E. Bezsonov Mirza S. Baig Tatyana V. Popkova Alexander N. Orekhov |
author_sort |
Siarhei A. Dabravolski |
title |
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases |
title_short |
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases |
title_full |
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases |
title_fullStr |
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases |
title_full_unstemmed |
Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases |
title_sort |
mitochondrial lipid homeostasis at the crossroads of liver and heart diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
The prevalence of NAFLD (non-alcoholic fatty liver disease) is a rapidly increasing problem, affecting a huge population around the globe. However, CVDs (cardiovascular diseases) are the most common cause of mortality in NAFLD patients. Atherogenic dyslipidemia, characterized by plasma hypertriglyceridemia, increased small dense LDL (low-density lipoprotein) particles, and decreased HDL-C (high-density lipoprotein cholesterol) levels, is often observed in NAFLD patients. In this review, we summarize recent genetic evidence, proving the diverse nature of metabolic pathways involved in NAFLD pathogenesis. Analysis of available genetic data suggests that the altered operation of fatty-acid β-oxidation in liver mitochondria is the key process, connecting NAFLD-mediated dyslipidemia and elevated CVD risk. In addition, we discuss several NAFLD-associated genes with documented anti-atherosclerotic or cardioprotective effects, and current pharmaceutical strategies focused on both NAFLD treatment and reduction of CVD risk. |
topic |
NAFLD cardiovascular disease dyslipidemia atherosclerosis fatty-acid β-oxidation lipid metabolism |
url |
https://www.mdpi.com/1422-0067/22/13/6949 |
work_keys_str_mv |
AT siarheiadabravolski mitochondriallipidhomeostasisatthecrossroadsofliverandheartdiseases AT evgenyebezsonov mitochondriallipidhomeostasisatthecrossroadsofliverandheartdiseases AT mirzasbaig mitochondriallipidhomeostasisatthecrossroadsofliverandheartdiseases AT tatyanavpopkova mitochondriallipidhomeostasisatthecrossroadsofliverandheartdiseases AT alexandernorekhov mitochondriallipidhomeostasisatthecrossroadsofliverandheartdiseases |
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1721299298718580736 |