Flavivirus Infection Associated with Cerebrovascular Events

Arthropod-borne viruses (arboviruses) of the genus <i>Flavivirus</i> are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hem...

Full description

Bibliographic Details
Main Authors: Cássia F. Estofolete, Bruno H. G. A. Milhim, Nathalia Zini, Samuel N. Scamardi, Joana D’Arc Selvante, Nikos Vasilakis, Maurício L. Nogueira
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/6/671
id doaj-26725178061d430fb7bb297bcac9d1a8
record_format Article
spelling doaj-26725178061d430fb7bb297bcac9d1a82020-11-25T02:25:37ZengMDPI AGViruses1999-49152020-06-011267167110.3390/v12060671Flavivirus Infection Associated with Cerebrovascular EventsCássia F. Estofolete0Bruno H. G. A. Milhim1Nathalia Zini2Samuel N. Scamardi3Joana D’Arc Selvante4Nikos Vasilakis5Maurício L. Nogueira6Department of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilDepartment of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilDepartment of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilDepartment of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilDepartment of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilDepartment of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609, USADepartment of Infectious, Dermatological and Parasitic Infections, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto 15090-000, BrazilArthropod-borne viruses (arboviruses) of the genus <i>Flavivirus</i> are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, São Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Our findings highlight the potential threat that unusual clinical manifestations may pose to arbovirus disease management and recovery.https://www.mdpi.com/1999-4915/12/6/671Zika virusdengue virusatypical manifestationscerebrovascular events
collection DOAJ
language English
format Article
sources DOAJ
author Cássia F. Estofolete
Bruno H. G. A. Milhim
Nathalia Zini
Samuel N. Scamardi
Joana D’Arc Selvante
Nikos Vasilakis
Maurício L. Nogueira
spellingShingle Cássia F. Estofolete
Bruno H. G. A. Milhim
Nathalia Zini
Samuel N. Scamardi
Joana D’Arc Selvante
Nikos Vasilakis
Maurício L. Nogueira
Flavivirus Infection Associated with Cerebrovascular Events
Viruses
Zika virus
dengue virus
atypical manifestations
cerebrovascular events
author_facet Cássia F. Estofolete
Bruno H. G. A. Milhim
Nathalia Zini
Samuel N. Scamardi
Joana D’Arc Selvante
Nikos Vasilakis
Maurício L. Nogueira
author_sort Cássia F. Estofolete
title Flavivirus Infection Associated with Cerebrovascular Events
title_short Flavivirus Infection Associated with Cerebrovascular Events
title_full Flavivirus Infection Associated with Cerebrovascular Events
title_fullStr Flavivirus Infection Associated with Cerebrovascular Events
title_full_unstemmed Flavivirus Infection Associated with Cerebrovascular Events
title_sort flavivirus infection associated with cerebrovascular events
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2020-06-01
description Arthropod-borne viruses (arboviruses) of the genus <i>Flavivirus</i> are distributed globally and cause significant human disease and mortality annually. Flavivirus infections present a spectrum of clinical manifestations, ranging from asymptomatic to severe manifestations, including hemorrhage, encephalitis and death. Herein, we describe 3 case reports of cerebrovascular involvement in patients infected by dengue and Zika viruses in Sao Jose do Rio Preto, São Paulo State, Brazil, a hyperendemic area for arbovirus circulation, including dengue, yellow fever, chikungunya and Saint Louis encephalitis viruses. Our findings highlight the potential threat that unusual clinical manifestations may pose to arbovirus disease management and recovery.
topic Zika virus
dengue virus
atypical manifestations
cerebrovascular events
url https://www.mdpi.com/1999-4915/12/6/671
work_keys_str_mv AT cassiafestofolete flavivirusinfectionassociatedwithcerebrovascularevents
AT brunohgamilhim flavivirusinfectionassociatedwithcerebrovascularevents
AT nathaliazini flavivirusinfectionassociatedwithcerebrovascularevents
AT samuelnscamardi flavivirusinfectionassociatedwithcerebrovascularevents
AT joanadarcselvante flavivirusinfectionassociatedwithcerebrovascularevents
AT nikosvasilakis flavivirusinfectionassociatedwithcerebrovascularevents
AT mauriciolnogueira flavivirusinfectionassociatedwithcerebrovascularevents
_version_ 1724850947995205632