Syringaresinol Inhibits UVA-Induced MMP-1 Expression by Suppression of MAPK/AP-1 Signaling in HaCaT Keratinocytes and Human Dermal Fibroblasts

Syringaresinol Inhibits UVA-Induced MMP-1 Expression by Suppression of MAPK/AP-1 Signaling in HaCaT Keratinocytes and Human Dermal Fibroblasts

Ultraviolet (UV) irradiation induces detrimental changes in human skin which result in photoaging. UV-induced intracellular changes cause degradation of extracellular matrix (ECM). UV-stimulated cleavage of collagen in ECM occurs via matrix metalloproteinases (MMPs). (±)-syringaresinol (SYR), a phyt...

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Bibliographic Details
Main Authors: Jung Hwan Oh, Yung Hyup Joo, Fatih Karadeniz, Jaeyoung Ko, Chang-Suk Kong
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
HaCaT keratinocytes
human dermal fibroblasts
MMP-1
photoaging
UVA
Online Access:https://www.mdpi.com/1422-0067/21/11/3981

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