It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding of two active G protein α-subunits (Gα*). To inves...
Main Authors: | Bilal M. Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Trevor D. Lamb, Klaus Peter Hofmann, Christian M. T. Spahn, Martin Heck |
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Format: | Article |
Language: | English |
Published: |
The Royal Society
2018-08-01
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Series: | Open Biology |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180075 |
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