Regulation of CAR and PXR Expression in Health and Disease
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of drug metabolism and disposition, and it is no...
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doaj-26a600fc3dfc47199e8caa61fd9c165b2020-11-25T04:02:57ZengMDPI AGCells2073-44092020-10-0192395239510.3390/cells9112395Regulation of CAR and PXR Expression in Health and DiseaseMartine Daujat-Chavanieu0Sabine Gerbal-Chaloin1IRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, FranceIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, FrancePregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of drug metabolism and disposition, and it is now well established that they are implicated in physiological and pathological conditions. Considerable efforts have been made to understand the regulation of their activity by their cognate ligand; however, additional regulatory mechanisms, among which the regulation of their expression, modulate their pleiotropic effects. This review summarizes the current knowledge on <i>CAR</i> and <i>PXR</i> expression during development and adult life; tissue distribution; spatial, temporal, and metabolic regulations; as well as in pathological situations, including chronic diseases and cancers. The expression of CAR and PXR is modulated by complex regulatory mechanisms that involve the interplay of transcription factors and also post-transcriptional and epigenetic modifications. Moreover, many environmental stimuli affect CAR and PXR expression through mechanisms that have not been elucidated.https://www.mdpi.com/2073-4409/9/11/2395CARPXRregulationexpression |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martine Daujat-Chavanieu Sabine Gerbal-Chaloin |
spellingShingle |
Martine Daujat-Chavanieu Sabine Gerbal-Chaloin Regulation of CAR and PXR Expression in Health and Disease Cells CAR PXR regulation expression |
author_facet |
Martine Daujat-Chavanieu Sabine Gerbal-Chaloin |
author_sort |
Martine Daujat-Chavanieu |
title |
Regulation of CAR and PXR Expression in Health and Disease |
title_short |
Regulation of CAR and PXR Expression in Health and Disease |
title_full |
Regulation of CAR and PXR Expression in Health and Disease |
title_fullStr |
Regulation of CAR and PXR Expression in Health and Disease |
title_full_unstemmed |
Regulation of CAR and PXR Expression in Health and Disease |
title_sort |
regulation of car and pxr expression in health and disease |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-10-01 |
description |
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are members of the nuclear receptor superfamily that mainly act as ligand-activated transcription factors. Their functions have long been associated with the regulation of drug metabolism and disposition, and it is now well established that they are implicated in physiological and pathological conditions. Considerable efforts have been made to understand the regulation of their activity by their cognate ligand; however, additional regulatory mechanisms, among which the regulation of their expression, modulate their pleiotropic effects. This review summarizes the current knowledge on <i>CAR</i> and <i>PXR</i> expression during development and adult life; tissue distribution; spatial, temporal, and metabolic regulations; as well as in pathological situations, including chronic diseases and cancers. The expression of CAR and PXR is modulated by complex regulatory mechanisms that involve the interplay of transcription factors and also post-transcriptional and epigenetic modifications. Moreover, many environmental stimuli affect CAR and PXR expression through mechanisms that have not been elucidated. |
topic |
CAR PXR regulation expression |
url |
https://www.mdpi.com/2073-4409/9/11/2395 |
work_keys_str_mv |
AT martinedaujatchavanieu regulationofcarandpxrexpressioninhealthanddisease AT sabinegerbalchaloin regulationofcarandpxrexpressioninhealthanddisease |
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1724441652594999296 |