Neuronal basis of innate olfactory attraction to ethanol in Drosophila.
The decision to move towards a mating partner or a food source is essential for life. The mechanisms underlying these behaviors are not well understood. Here, we investigated the role of octopamine - the invertebrate analogue of noradrenaline - in innate olfactory attraction to ethanol. We confirmed...
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doaj-26b03549f36b430584debd2f3e6bf7f22020-11-24T21:49:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5200710.1371/journal.pone.0052007Neuronal basis of innate olfactory attraction to ethanol in Drosophila.Andrea SchneiderManuela RuppertOliver HendrichThomas GiangMaite OguetaStefanie HampelMarvin VollbachAnsgar BüschgesHenrike ScholzThe decision to move towards a mating partner or a food source is essential for life. The mechanisms underlying these behaviors are not well understood. Here, we investigated the role of octopamine - the invertebrate analogue of noradrenaline - in innate olfactory attraction to ethanol. We confirmed that preference is caused via an olfactory stimulus by dissecting the function of the olfactory co-receptor Orco (formally known as OR83b). Orco function is not required for ethanol recognition per se, however it plays a role in context dependent recognition of ethanol. Odor-evoked ethanol preference requires the function of Tbh (Tyramine β hydroxalyse), the rate-limiting enzyme of octopamine synthesis. In addition, neuronal activity in a subset of octopaminergic neurons is necessary for olfactory ethanol preference. Notably, a specific neuronal activation pattern of tyraminergic/octopaminergic neurons elicit preference and is therefore sufficient to induce preference. In contrast, dopamine dependent increase in locomotor activity is not sufficient for olfactory ethanol preference. Consistent with the role of noradrenaline in mammalian drug induced rewards, we provide evidence that in adult Drosophila the octopaminergic neurotransmitter functions as a reinforcer and that the molecular dissection of the innate attraction to ethanol uncovers the basic properties of a response selection system.http://europepmc.org/articles/PMC3527413?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Schneider Manuela Ruppert Oliver Hendrich Thomas Giang Maite Ogueta Stefanie Hampel Marvin Vollbach Ansgar Büschges Henrike Scholz |
spellingShingle |
Andrea Schneider Manuela Ruppert Oliver Hendrich Thomas Giang Maite Ogueta Stefanie Hampel Marvin Vollbach Ansgar Büschges Henrike Scholz Neuronal basis of innate olfactory attraction to ethanol in Drosophila. PLoS ONE |
author_facet |
Andrea Schneider Manuela Ruppert Oliver Hendrich Thomas Giang Maite Ogueta Stefanie Hampel Marvin Vollbach Ansgar Büschges Henrike Scholz |
author_sort |
Andrea Schneider |
title |
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. |
title_short |
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. |
title_full |
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. |
title_fullStr |
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. |
title_full_unstemmed |
Neuronal basis of innate olfactory attraction to ethanol in Drosophila. |
title_sort |
neuronal basis of innate olfactory attraction to ethanol in drosophila. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
The decision to move towards a mating partner or a food source is essential for life. The mechanisms underlying these behaviors are not well understood. Here, we investigated the role of octopamine - the invertebrate analogue of noradrenaline - in innate olfactory attraction to ethanol. We confirmed that preference is caused via an olfactory stimulus by dissecting the function of the olfactory co-receptor Orco (formally known as OR83b). Orco function is not required for ethanol recognition per se, however it plays a role in context dependent recognition of ethanol. Odor-evoked ethanol preference requires the function of Tbh (Tyramine β hydroxalyse), the rate-limiting enzyme of octopamine synthesis. In addition, neuronal activity in a subset of octopaminergic neurons is necessary for olfactory ethanol preference. Notably, a specific neuronal activation pattern of tyraminergic/octopaminergic neurons elicit preference and is therefore sufficient to induce preference. In contrast, dopamine dependent increase in locomotor activity is not sufficient for olfactory ethanol preference. Consistent with the role of noradrenaline in mammalian drug induced rewards, we provide evidence that in adult Drosophila the octopaminergic neurotransmitter functions as a reinforcer and that the molecular dissection of the innate attraction to ethanol uncovers the basic properties of a response selection system. |
url |
http://europepmc.org/articles/PMC3527413?pdf=render |
work_keys_str_mv |
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