Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting
It has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary ar...
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doaj-26b0d92aa31f41eaacdc32d70a5392a72020-11-25T00:56:34ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/79517937951793Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass GraftingShu Xu0Jian Zhang1Yin-li Xu2Hai-bo Wu3Xiao-dong Xue4Hui-shan Wang5Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, ChinaDepartment of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, ChinaDepartment of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, ChinaDepartment of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, ChinaDepartment of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, ChinaDepartment of Cardiovascular Surgery, General Hospital of Shenyang Military Region, No. 83, Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, ChinaIt has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary artery bypass grafting (OPCABG) remains a question. The concentrations of serum ACE, angiotensin II (Ang II), apelin, bradykinin (BK), malondialdehyde (MDA), and C reactive protein (CRP) were measured in the perioperative period of OPCABG. The levels of serum ACE in the POAF group were higher than in the no POAF group both preoperatively and postoperatively. Apelin in the POAF group was lower than in the no POAF group. There was a correlation between serum ACE and apelin. Postoperatively, CRP and MDA in the POAF group were higher than in the no POAF group; however, there was no difference before the operation. Preoperative ACE and apelin were both significant and independent risk factors for POAF. In conclusion, the high ACE and low apelin preoperatively led to CRP and MDA being increased postoperatively, which was probably associated with POAF after OPCABG. Apelin may be a new predictor for POAF.http://dx.doi.org/10.1155/2017/7951793 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shu Xu Jian Zhang Yin-li Xu Hai-bo Wu Xiao-dong Xue Hui-shan Wang |
spellingShingle |
Shu Xu Jian Zhang Yin-li Xu Hai-bo Wu Xiao-dong Xue Hui-shan Wang Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting BioMed Research International |
author_facet |
Shu Xu Jian Zhang Yin-li Xu Hai-bo Wu Xiao-dong Xue Hui-shan Wang |
author_sort |
Shu Xu |
title |
Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting |
title_short |
Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting |
title_full |
Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting |
title_fullStr |
Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting |
title_full_unstemmed |
Relationship between Angiotensin Converting Enzyme, Apelin, and New-Onset Atrial Fibrillation after Off-Pump Coronary Artery Bypass Grafting |
title_sort |
relationship between angiotensin converting enzyme, apelin, and new-onset atrial fibrillation after off-pump coronary artery bypass grafting |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
It has been shown that inflammation and oxidative stress are important factors in postoperative atrial fibrillation (POAF). Angiotensin converting enzyme (ACE) and apelin have a close relationship with inflammation and oxidative stress. The effect of ACE and apelin on POAF after off-pump coronary artery bypass grafting (OPCABG) remains a question. The concentrations of serum ACE, angiotensin II (Ang II), apelin, bradykinin (BK), malondialdehyde (MDA), and C reactive protein (CRP) were measured in the perioperative period of OPCABG. The levels of serum ACE in the POAF group were higher than in the no POAF group both preoperatively and postoperatively. Apelin in the POAF group was lower than in the no POAF group. There was a correlation between serum ACE and apelin. Postoperatively, CRP and MDA in the POAF group were higher than in the no POAF group; however, there was no difference before the operation. Preoperative ACE and apelin were both significant and independent risk factors for POAF. In conclusion, the high ACE and low apelin preoperatively led to CRP and MDA being increased postoperatively, which was probably associated with POAF after OPCABG. Apelin may be a new predictor for POAF. |
url |
http://dx.doi.org/10.1155/2017/7951793 |
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