Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition
Abstract It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing su...
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doaj-26bbf528fb0a4db88e483d99c71ac0972020-11-25T02:38:06ZengWileyAdvanced Science2198-38442020-03-0176n/an/a10.1002/advs.201902847Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy InhibitionBowen Yang0Li Ding1Yu Chen2Jianlin Shi3State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaAbstract It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor‐starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor‐specific cancer therapies in the future.https://doi.org/10.1002/advs.201902847autophagyblack phosphorusglycolysisnanomedicinetumor‐starvation therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bowen Yang Li Ding Yu Chen Jianlin Shi |
spellingShingle |
Bowen Yang Li Ding Yu Chen Jianlin Shi Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition Advanced Science autophagy black phosphorus glycolysis nanomedicine tumor‐starvation therapy |
author_facet |
Bowen Yang Li Ding Yu Chen Jianlin Shi |
author_sort |
Bowen Yang |
title |
Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition |
title_short |
Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition |
title_full |
Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition |
title_fullStr |
Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition |
title_full_unstemmed |
Augmenting Tumor‐Starvation Therapy by Cancer Cell Autophagy Inhibition |
title_sort |
augmenting tumor‐starvation therapy by cancer cell autophagy inhibition |
publisher |
Wiley |
series |
Advanced Science |
issn |
2198-3844 |
publishDate |
2020-03-01 |
description |
Abstract It was recently recognized that cancer therapeutic efficacy may be greatly compromised by an intrinsic protective mechanism called autophagy, by which cancer cells survive in harsh conditions such as starvation. Here, a synergetic strategy is described for cancer treatment by suppressing such a protective mechanism for augmenting tumor‐starvation therapy. The synergetic therapy is achieved by restraining glucose metabolism using an antiglycolytic agent to predispose cancer cells to severe energy deprivation; concurrently the downstream autophagic flux and compensatory energy supplies are blocked by the autophagy inhibitor black phosphorus nanosheet. Cancer cells fail to extract their own nutrient to feed themselves, finally succumbing to therapeutic interventions and starving to death. Both in vitro and in vivo results evidence the cooperative effect between the autophagy inhibitor and antiglycolytic agent, which leads to remarkable synergetic antineoplastic outcome. It is expected that such a combinational approach by concurrently blocking exogenous and endogenous nutrition supplies will be beneficial to the design of effective tumor‐specific cancer therapies in the future. |
topic |
autophagy black phosphorus glycolysis nanomedicine tumor‐starvation therapy |
url |
https://doi.org/10.1002/advs.201902847 |
work_keys_str_mv |
AT bowenyang augmentingtumorstarvationtherapybycancercellautophagyinhibition AT liding augmentingtumorstarvationtherapybycancercellautophagyinhibition AT yuchen augmentingtumorstarvationtherapybycancercellautophagyinhibition AT jianlinshi augmentingtumorstarvationtherapybycancercellautophagyinhibition |
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