Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.

Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.

Radiotherapy is one of the major therapeutic strategies in cancer treatment. The telomere-binding protein TPP1 is an important component of the shelterin complex at mammalian telomeres. Our previous reports showed that TPP1 expression was elevated in radioresistant cells, but the exact effects and m...

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Bibliographic Details
Main Authors: Lei Yang, Wenbo Wang, Liu Hu, Xiaoxi Yang, Juan Zhong, Zheng Li, Hui Yang, Han Lei, Haijun Yu, ZhengKai Liao, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3834294?pdf=render

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