Expression of β1 adrenergic receptor in vascular anomalies in children
Objective Controversial, heterogeneous, and inconsistent responses to beta-blockers have been reported in some cases of infantile proliferative hemangiomas. On the basis of these clinical observations, we aimed to examine the β1 adrenergic receptor (β1-AR) protein expression distribution among diffe...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2021-09-01
|
Series: | Journal of International Medical Research |
Online Access: | https://doi.org/10.1177/03000605211047713 |
id |
doaj-26d4fffe6746499ca65f2ae9f53a3638 |
---|---|
record_format |
Article |
spelling |
doaj-26d4fffe6746499ca65f2ae9f53a36382021-09-30T23:34:07ZengSAGE PublishingJournal of International Medical Research1473-23002021-09-014910.1177/03000605211047713Expression of β1 adrenergic receptor in vascular anomalies in childrenMaria-Corina StănciulescuMarius-Călin PopoiuAnca Maria CîmpeanVlad-Laurentiu DavidRodica HeredeaSimona CerbuEugen-Sorin BoiaObjective Controversial, heterogeneous, and inconsistent responses to beta-blockers have been reported in some cases of infantile proliferative hemangiomas. On the basis of these clinical observations, we aimed to examine the β1 adrenergic receptor (β1-AR) protein expression distribution among different types of pediatric vascular anomalies. Methods Immunohistochemistry (IHC) was performed for β1-AR on 43 surgical specimens. Results We found positive β1-AR IHC staining in all intramuscular hemangiomas, capillary–lymphatic, lymphatic, venous, and combined malformations, and Masson’s tumor cases, as well as in 7 of 10 cases of proliferative infantile hemangiomas. Conclusions Our research demonstrates, for the first time, the degree of heterogeneous expression of β1-AR among pediatric vascular malformations. Our results support the need for β1-AR assessment in pediatric vascular anomalies to select cases with a robust response to β1-selective blockers. β1-AR assessment may have a strong impact on therapeutic refinement for pediatric vascular anomalies by selecting cases with a stronger response to beta-blockers.https://doi.org/10.1177/03000605211047713 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria-Corina Stănciulescu Marius-Călin Popoiu Anca Maria Cîmpean Vlad-Laurentiu David Rodica Heredea Simona Cerbu Eugen-Sorin Boia |
spellingShingle |
Maria-Corina Stănciulescu Marius-Călin Popoiu Anca Maria Cîmpean Vlad-Laurentiu David Rodica Heredea Simona Cerbu Eugen-Sorin Boia Expression of β1 adrenergic receptor in vascular anomalies in children Journal of International Medical Research |
author_facet |
Maria-Corina Stănciulescu Marius-Călin Popoiu Anca Maria Cîmpean Vlad-Laurentiu David Rodica Heredea Simona Cerbu Eugen-Sorin Boia |
author_sort |
Maria-Corina Stănciulescu |
title |
Expression of β1 adrenergic receptor in vascular anomalies in children |
title_short |
Expression of β1 adrenergic receptor in vascular anomalies in children |
title_full |
Expression of β1 adrenergic receptor in vascular anomalies in children |
title_fullStr |
Expression of β1 adrenergic receptor in vascular anomalies in children |
title_full_unstemmed |
Expression of β1 adrenergic receptor in vascular anomalies in children |
title_sort |
expression of β1 adrenergic receptor in vascular anomalies in children |
publisher |
SAGE Publishing |
series |
Journal of International Medical Research |
issn |
1473-2300 |
publishDate |
2021-09-01 |
description |
Objective Controversial, heterogeneous, and inconsistent responses to beta-blockers have been reported in some cases of infantile proliferative hemangiomas. On the basis of these clinical observations, we aimed to examine the β1 adrenergic receptor (β1-AR) protein expression distribution among different types of pediatric vascular anomalies. Methods Immunohistochemistry (IHC) was performed for β1-AR on 43 surgical specimens. Results We found positive β1-AR IHC staining in all intramuscular hemangiomas, capillary–lymphatic, lymphatic, venous, and combined malformations, and Masson’s tumor cases, as well as in 7 of 10 cases of proliferative infantile hemangiomas. Conclusions Our research demonstrates, for the first time, the degree of heterogeneous expression of β1-AR among pediatric vascular malformations. Our results support the need for β1-AR assessment in pediatric vascular anomalies to select cases with a robust response to β1-selective blockers. β1-AR assessment may have a strong impact on therapeutic refinement for pediatric vascular anomalies by selecting cases with a stronger response to beta-blockers. |
url |
https://doi.org/10.1177/03000605211047713 |
work_keys_str_mv |
AT mariacorinastanciulescu expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT mariuscalinpopoiu expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT ancamariacimpean expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT vladlaurentiudavid expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT rodicaheredea expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT simonacerbu expressionofb1adrenergicreceptorinvascularanomaliesinchildren AT eugensorinboia expressionofb1adrenergicreceptorinvascularanomaliesinchildren |
_version_ |
1716862608154296320 |