Research on influence of interferon on immune stress and HMGB1, MIF, GM-CSF in patients with condyloma acuminatum

Objective: To observe the influence of interferon on immune stress and HMGB1, MIF, GMCSF in patients with condyloma acuminatum. Methods: A total of 240 cases of patients with condyloma acuminatum were randomly divided into two groups, control group and observation group, each group of 120 cases. Th...

Full description

Bibliographic Details
Main Author: Han-Chun Yan
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2016-04-01
Series:Journal of Hainan Medical University
Subjects:
MIF
Online Access:http://www.hnykdxxb.com/PDF/201608/28.pdf
Description
Summary:Objective: To observe the influence of interferon on immune stress and HMGB1, MIF, GMCSF in patients with condyloma acuminatum. Methods: A total of 240 cases of patients with condyloma acuminatum were randomly divided into two groups, control group and observation group, each group of 120 cases. The CO2 laser was used for the removal of warts in all patients, while patients in the observation group were combined with interferon. Then the differences of curative effect and the recurrence of patients between the two groups were compared, and the change of T-lymphocyte subsets and serum inflammatory cytokines, HMGB1, MIF, GMCSF in the two groups were compared before and after treatment. Results: The cure rate of observation group was 88.33%, significantly higher than that of control group by 65%. The recurrence rate of the observation group was 10.83% which was significantly lower than that of the control group by 30.83%. Three, six months after treatment, the CD4+ and CD4+/CD8+ of patients in observation group were significantly higher than those in the control group, and CD8+ was significantly lower than that in the control group; the serum levels of IL-2 and IFN-γ were notably higher than those of control group, while the IL-4, IL-10 levels of patients were lower than those in control group; the serum levels of HMGB1, MIF, GM-CSF were lower than control group too. The difference between groups was statistically significant. Conclusion: Interferon can regulate T-lymphocyte subsets, inhibit inflammatory reaction and change the immune stress state, thereby profitably improving the cure rate and reduce the recurrence rate of CA patients.
ISSN:1007-1237
1007-1237