Cognitive reserve and the severity of Alzheimer’s disease
Alzheimer´s disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative pr...
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doaj-26da8c117ed54c51a9edaa86f686cfa52020-11-24T23:58:40ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-06-0173648048610.1590/0004-282X20150044S0004-282X2015000600480Cognitive reserve and the severity of Alzheimer’s diseaseMargarida SobralMaria Helena PestanaConstança PaúlAlzheimer´s disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD. Method This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, “Participation in leisure activities throughout life” and CR Questionnaire.Result The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015).Conclusion The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600480&lng=en&tlng=endoença de Alzheimerreserva cognitivaeducaçãoatividades de lazerocupação ao longo da vida |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Margarida Sobral Maria Helena Pestana Constança Paúl |
spellingShingle |
Margarida Sobral Maria Helena Pestana Constança Paúl Cognitive reserve and the severity of Alzheimer’s disease Arquivos de Neuro-Psiquiatria doença de Alzheimer reserva cognitiva educação atividades de lazer ocupação ao longo da vida |
author_facet |
Margarida Sobral Maria Helena Pestana Constança Paúl |
author_sort |
Margarida Sobral |
title |
Cognitive reserve and the severity of Alzheimer’s disease |
title_short |
Cognitive reserve and the severity of Alzheimer’s disease |
title_full |
Cognitive reserve and the severity of Alzheimer’s disease |
title_fullStr |
Cognitive reserve and the severity of Alzheimer’s disease |
title_full_unstemmed |
Cognitive reserve and the severity of Alzheimer’s disease |
title_sort |
cognitive reserve and the severity of alzheimer’s disease |
publisher |
Academia Brasileira de Neurologia (ABNEURO) |
series |
Arquivos de Neuro-Psiquiatria |
issn |
1678-4227 |
publishDate |
2015-06-01 |
description |
Alzheimer´s disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD. Method This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, “Participation in leisure activities throughout life” and CR Questionnaire.Result The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015).Conclusion The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD. |
topic |
doença de Alzheimer reserva cognitiva educação atividades de lazer ocupação ao longo da vida |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600480&lng=en&tlng=en |
work_keys_str_mv |
AT margaridasobral cognitivereserveandtheseverityofalzheimersdisease AT mariahelenapestana cognitivereserveandtheseverityofalzheimersdisease AT constancapaul cognitivereserveandtheseverityofalzheimersdisease |
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1725450429392748544 |