On the Spatial Organization of mRNA, Plasmids, and Ribosomes in a Bacterial Host Overexpressing Membrane Proteins.
By using fluorescence imaging, we provide a time-resolved single-cell view on coupled defects in transcription, translation, and growth during expression of heterologous membrane proteins in Lactococcus lactis. Transcripts encoding poorly produced membrane proteins accumulate in mRNA-dense bodies at...
Main Authors: | Lieke A van Gijtenbeek, Andrew Robinson, Antoine M van Oijen, Bert Poolman, Jan Kok |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-12-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5201305?pdf=render |
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