Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus
Abstract Background We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods...
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doaj-26e80d7813224f93a0773998bf011ebf2021-05-30T11:21:02ZengBMCHealth and Quality of Life Outcomes1477-75252021-05-0119111210.1186/s12955-021-01777-xImpact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virusEvy Yunihastuti0Fhadilla Amelia1Arini Ika Hapsari2Bramantya Wicaksana3Veritea Natali4Alvina Widhani5Andri Sanityoso Sulaiman6Teguh Harjono Karjadi7Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo HospitalHIV Integrated Services, Ciptomangunkusumo HospitalHIV Integrated Services, Ciptomangunkusumo HospitalHIV Integrated Services, Ciptomangunkusumo HospitalHIV Integrated Services, Ciptomangunkusumo HospitalAllergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo HospitalHepatobilliary Division, Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaAllergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Ciptomangunkusumo HospitalAbstract Background We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods A prospective study was performed in the HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. HCV/HIV co-infected patients who started sofosbuvir and daclatasvir from government free DAA program in 2017–2019. WHOQoL-HIV BREF and RAND SF-36 questionnaires were recorded at baseline and post-treatment week 12. Results 145 patients with mean age of 37.8 years (SD = 4.2) were included in the analysis. Most of patients were male (89%), previous IVDU (89%), active smoker (50.4%) and non-cirrhosis (80%). SVR12 was achieved in 95.5% of patients. Sofosbuvir and daclatasvir treatments showed positive impacts on 2 domains and 2 other items of WHOQoL-HIV BREF and 2 domains and 1 item of SF-36. Predicting factors of significant increase in each domain/item were: male and normal body mass index (BMI) for level of independence (RR 4.01,95% CI 1.09–14.74 and 4.80,95% CI 1.79–12.81); higher HCV-RNA for overall perception of QoL (RR 0.42,95% CI 0.18–0.94); non-smoking status for overall perception of health (RR 0.32,95% CI 0.15–0.66); male and fibrosis stage 0–1 for general health (RR 6.21,95% CI 1.69–22.88 and 2.86,95% CI 1.16–7.00); and the use of NNRTI-based ART (RR 5.23, 95% CI 1.16–23.65). Spiritual/personal belief decline was predicted by non-smoking status (RR 0.46, 95% CI 0.23–0.95). Treatment success was not associated with any changes of HR-QoL domain/item. Conclusions HCV/HIV co-infected patients were successfully treated with sofosbuvir and daclatasvir and experienced improvement of HRQoL 12 weeks after treatment completion.https://doi.org/10.1186/s12955-021-01777-xHealth-related quality of lifeHepatitis CHCVHIVSofosbuvirDaclastavir |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Evy Yunihastuti Fhadilla Amelia Arini Ika Hapsari Bramantya Wicaksana Veritea Natali Alvina Widhani Andri Sanityoso Sulaiman Teguh Harjono Karjadi |
spellingShingle |
Evy Yunihastuti Fhadilla Amelia Arini Ika Hapsari Bramantya Wicaksana Veritea Natali Alvina Widhani Andri Sanityoso Sulaiman Teguh Harjono Karjadi Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus Health and Quality of Life Outcomes Health-related quality of life Hepatitis C HCV HIV Sofosbuvir Daclastavir |
author_facet |
Evy Yunihastuti Fhadilla Amelia Arini Ika Hapsari Bramantya Wicaksana Veritea Natali Alvina Widhani Andri Sanityoso Sulaiman Teguh Harjono Karjadi |
author_sort |
Evy Yunihastuti |
title |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
title_short |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
title_full |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
title_fullStr |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
title_full_unstemmed |
Impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis C and human immunodeficiency virus |
title_sort |
impact of sofosbuvir and daclastavir on health-related quality of life in patients co-infected with hepatitis c and human immunodeficiency virus |
publisher |
BMC |
series |
Health and Quality of Life Outcomes |
issn |
1477-7525 |
publishDate |
2021-05-01 |
description |
Abstract Background We conducted a real-life study of health-related quality of life (HRQoL) transformation before and 12 weeks after sofosbuvir and daclatasvir therapy in HCV/HIV co-infected patients. Factors related to the significant changes of each HRQoL domain/item were also evaluated. Methods A prospective study was performed in the HIV integrated clinic at Cipto Mangunkusumo Hospital, Jakarta. HCV/HIV co-infected patients who started sofosbuvir and daclatasvir from government free DAA program in 2017–2019. WHOQoL-HIV BREF and RAND SF-36 questionnaires were recorded at baseline and post-treatment week 12. Results 145 patients with mean age of 37.8 years (SD = 4.2) were included in the analysis. Most of patients were male (89%), previous IVDU (89%), active smoker (50.4%) and non-cirrhosis (80%). SVR12 was achieved in 95.5% of patients. Sofosbuvir and daclatasvir treatments showed positive impacts on 2 domains and 2 other items of WHOQoL-HIV BREF and 2 domains and 1 item of SF-36. Predicting factors of significant increase in each domain/item were: male and normal body mass index (BMI) for level of independence (RR 4.01,95% CI 1.09–14.74 and 4.80,95% CI 1.79–12.81); higher HCV-RNA for overall perception of QoL (RR 0.42,95% CI 0.18–0.94); non-smoking status for overall perception of health (RR 0.32,95% CI 0.15–0.66); male and fibrosis stage 0–1 for general health (RR 6.21,95% CI 1.69–22.88 and 2.86,95% CI 1.16–7.00); and the use of NNRTI-based ART (RR 5.23, 95% CI 1.16–23.65). Spiritual/personal belief decline was predicted by non-smoking status (RR 0.46, 95% CI 0.23–0.95). Treatment success was not associated with any changes of HR-QoL domain/item. Conclusions HCV/HIV co-infected patients were successfully treated with sofosbuvir and daclatasvir and experienced improvement of HRQoL 12 weeks after treatment completion. |
topic |
Health-related quality of life Hepatitis C HCV HIV Sofosbuvir Daclastavir |
url |
https://doi.org/10.1186/s12955-021-01777-x |
work_keys_str_mv |
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