Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study
Abstract Background The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. Hypothesis/Objectives To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possi...
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Online Access: | https://doi.org/10.1111/jvim.16054 |
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doaj-26f4cdb9fb07499fa4a4a06999dc70c02021-03-26T10:53:08ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-03-0135278980010.1111/jvim.16054Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field studyKarsten E. Schober0John E. Rush1Virginia Luis Fuentes2Tony Glaus3Nuala J. Summerfield4Kathy Wright5Linda Lehmkuhl6Gerhard Wess7Margaret P. Sayer8Joao Loureiro9John MacGregor10Nicole Mohren11The Ohio State University Department of Veterinary Clinical Sciences Columbus Ohio USACummings School of Veterinary Medicine Tufts University North Grafton Massachusetts USARoyal Veterinary College Clinical Sciences and Services London UKUniversity of Zürich Clinic for Small Animal Internal Medicine Zürich SwitzerlandNorth Downs Specialist Referrals Bletchingley UKMedVet Cincinnati and Dayton Ohio USAMedVet Columbus Ohio USAUniversity of Munich Clinic of Small Animal Medicine Munich GermanyCharlotte Animal Referral & Emergency Charlotte North Carolina USANorth Downs Specialist Referrals Bletchingley UKNew England Veterinary Cardiology Durham North Carolina USABoehringer Ingelheim Vetmedica GmbH Ingelheim GermanyAbstract Background The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. Hypothesis/Objectives To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible endpoints for a pivotal study. We hypothesized that pimobendan would be well‐tolerated and associated with improved outcome. Animals Eighty‐three cats with HCM and recently controlled CHF: 30 with and 53 without left ventricular outflow tract obstruction. Methods Prospective randomized placebo‐controlled double‐blind multicenter nonpivotal field study. Cats received either pimobendan (0.30 mg/kg q12h, n = 43), placebo (n = 39), or no medication (n = 1) together with furosemide (<10 mg/kg/d) with or without clopidogrel. The primary endpoint was a successful outcome (ie, completing the 180‐day study period without a dose escalation of furosemide). Results The proportion of cats in the full analysis set population with a successful outcome was not different between treatment groups (P = .75). For nonobstructive cats, the success rate was 32% in pimobendan‐treated cats versus 18.2% in the placebo group (odds ratio [OR], 2.12; 95% confidence interval [CI], 0.54‐8.34). For obstructive cats, the success rate was 28.6% and 60% in the pimobendan and placebo groups, respectively (OR, 0.27; 95% CI, 0.06‐1.26). No difference was found between treatments for the secondary endpoints of time to furosemide dose escalation or death (P = .89). Results were similar in the per‐protocol sets. Adverse events in both treatment groups were similar. Conclusions and Clinical Importance In this study of cats with HCM and recent CHF, no benefit of pimobendan on 180‐day outcome was identified.https://doi.org/10.1111/jvim.16054clinical trialdynamic outflow tract obstructionfelinepositive inotropesurvivaltreatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karsten E. Schober John E. Rush Virginia Luis Fuentes Tony Glaus Nuala J. Summerfield Kathy Wright Linda Lehmkuhl Gerhard Wess Margaret P. Sayer Joao Loureiro John MacGregor Nicole Mohren |
spellingShingle |
Karsten E. Schober John E. Rush Virginia Luis Fuentes Tony Glaus Nuala J. Summerfield Kathy Wright Linda Lehmkuhl Gerhard Wess Margaret P. Sayer Joao Loureiro John MacGregor Nicole Mohren Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study Journal of Veterinary Internal Medicine clinical trial dynamic outflow tract obstruction feline positive inotrope survival treatment |
author_facet |
Karsten E. Schober John E. Rush Virginia Luis Fuentes Tony Glaus Nuala J. Summerfield Kathy Wright Linda Lehmkuhl Gerhard Wess Margaret P. Sayer Joao Loureiro John MacGregor Nicole Mohren |
author_sort |
Karsten E. Schober |
title |
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
title_short |
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
title_full |
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
title_fullStr |
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
title_full_unstemmed |
Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
title_sort |
effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study |
publisher |
Wiley |
series |
Journal of Veterinary Internal Medicine |
issn |
0891-6640 1939-1676 |
publishDate |
2021-03-01 |
description |
Abstract Background The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. Hypothesis/Objectives To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible endpoints for a pivotal study. We hypothesized that pimobendan would be well‐tolerated and associated with improved outcome. Animals Eighty‐three cats with HCM and recently controlled CHF: 30 with and 53 without left ventricular outflow tract obstruction. Methods Prospective randomized placebo‐controlled double‐blind multicenter nonpivotal field study. Cats received either pimobendan (0.30 mg/kg q12h, n = 43), placebo (n = 39), or no medication (n = 1) together with furosemide (<10 mg/kg/d) with or without clopidogrel. The primary endpoint was a successful outcome (ie, completing the 180‐day study period without a dose escalation of furosemide). Results The proportion of cats in the full analysis set population with a successful outcome was not different between treatment groups (P = .75). For nonobstructive cats, the success rate was 32% in pimobendan‐treated cats versus 18.2% in the placebo group (odds ratio [OR], 2.12; 95% confidence interval [CI], 0.54‐8.34). For obstructive cats, the success rate was 28.6% and 60% in the pimobendan and placebo groups, respectively (OR, 0.27; 95% CI, 0.06‐1.26). No difference was found between treatments for the secondary endpoints of time to furosemide dose escalation or death (P = .89). Results were similar in the per‐protocol sets. Adverse events in both treatment groups were similar. Conclusions and Clinical Importance In this study of cats with HCM and recent CHF, no benefit of pimobendan on 180‐day outcome was identified. |
topic |
clinical trial dynamic outflow tract obstruction feline positive inotrope survival treatment |
url |
https://doi.org/10.1111/jvim.16054 |
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